Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry
文献类型：期刊论文
| 作者 | Wang, Cai-yun1; Xu, Fen1; Sun, Li-xian2; Sun, Yu-Jia3; Qiu, Shu-jun4; Zhao, Zhong-bao2; Tan, Hai-dong2; Wang, Shuang2 |
| 刊名 | journal of thermal analysis and calorimetry
 |
| 出版日期 | 2013 |
| 卷号 | 111期号:1页码:959-963 |
| 关键词 | Microcalorimetry E. coli Levofloxacin lactate Levofloxacin hydrochloride |
| 产权排序 | 待补充 |
| 通讯作者 | 孙立贤 |
| 合作状况 | 英 |
| 英文摘要 | a microcalorimetric technique was used to evaluate the influence of both levofloxacin lactate in sodium chloride injection (drug a) and levofloxacin hydrochloride in sodium chloride injection (drug b) on the metabolism of escherichia coli. by means of an isothermal calorimeter and ampoule method at 37 a degrees c, the power-time curves of e. coli growth were obtained under different conditions. the parameters such as the growth rate constant k, maximum power output p (m), time t (m) corresponding to the maximum power output and inhibitory ratio i of these two drugs were obtained. the results reveal that the inhibitory abilities enhance with increasing concentrations of the two drugs. the critical growth concentration and the half-inhibitory concentration ic50 were 0.15 and 0.079 mu g ml(-1) (for drug a), 0.13 and 0.061 mu g ml(-1) (for drug b), respectively. these results show the drug a has slightly better inhibitory effect on e. coli than that of drug b. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, analytical ; chemistry, physical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | isothermal microcalorimetry ; antibacterial activity ; growth ; antibiotics ; dh5-alpha |
| 收录类别 | SCI |
| 资助信息 | 2，3 |
| 原文出处 | 963 |
| 语种 | 英语 |
| WOS记录号 | WOS:000313207400123 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119377]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Liaoning Normal Univ, Coll Chem & Chem Engn, Dalian 116029, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Mat & Thermochem Lab, Dalian 116023, Peoples R China 3.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China 4.Guilin Univ Elect Technol, Sch Mat Sci & Engn, Guilin 541004, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Cai-yun,Xu, Fen,Sun, Li-xian,et al. Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry[J]. journal of thermal analysis and calorimetry,2013,111(1):959-963. |
| APA | Wang, Cai-yun.,Xu, Fen.,Sun, Li-xian.,Sun, Yu-Jia.,Qiu, Shu-jun.,...&Wang, Shuang.(2013).Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry.journal of thermal analysis and calorimetry,111(1),959-963. |
| MLA | Wang, Cai-yun,et al."Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry".journal of thermal analysis and calorimetry 111.1(2013):959-963. |
入库方式： OAI收割
来源：大连化学物理研究所
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