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Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo
文献类型：期刊论文
| 作者 | Yu, Fabiao; Li, Peng; Wang, Bingshuai; Han, Keli |
| 刊名 | journal of the american chemical society
 |
| 出版日期 | 2013-05-22 |
| 卷号 | 135期号:20页码:7674-7680 |
| 产权排序 | 待补充 |
| 通讯作者 | 韩克利 |
| 合作状况 | 英 |
| 英文摘要 | the redox homeostasis between peroxynitrite and glutathione is closely associated with the physiological and pathological processes, e.g. vascular tissue prolonged relaxation and smooth muscle preparations, attenuation hepatic necrosis, and activation matrix metalloproteinase-2. we report a near-infrared fluorescent probe based on heptamethine cyanine, which integrates with telluroenzyme mimics for monitoring the changes of onoo-/gsh levels in cells and in vivo. the probe can reversibly respond to onoo- and gsh and exhibits high selectivity, sensitivity, and mitochondrial target. it is successfully applied to visualize the changes of redox cycles during the outbreak of onoo- and the antioxidant gsh repair in cells and animal. the probe would provide a significant advance on the redox events involved in the cellular redox regulation. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | thiols reducing repair ; h2o2 oxidative stress ; living cells ; nitric-oxide ; reactive oxygen ; tyrosine nitration ; biological-systems ; superoxide ; bodipy ; mitochondria |
| 收录类别 | SCI ; IC |
| 资助信息 | 1，1 |
| 原文出处 | 7680 |
| 语种 | 英语 |
| WOS记录号 | WOS:000319551000041 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119406]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Moleclar React Dynam, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Fabiao,Li, Peng,Wang, Bingshuai,et al. Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo[J]. journal of the american chemical society,2013,135(20):7674-7680. |
| APA | Yu, Fabiao,Li, Peng,Wang, Bingshuai,&Han, Keli.(2013).Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo.journal of the american chemical society,135(20),7674-7680. |
| MLA | Yu, Fabiao,et al."Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo".journal of the american chemical society 135.20(2013):7674-7680. |
入库方式： OAI收割
来源：大连化学物理研究所
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