Synthesis of NAD analogs to develop bioorthogonal redox system
文献类型：期刊论文
| 作者 | Ji DeBin1; Wang Lei1; Liu WuJun1,2; Hou ShuHua1; ZongBao, Zhao K.1,2,3 |
| 刊名 | science china-chemistry
 |
| 出版日期 | 2013-03-01 |
| 卷号 | 56期号:3页码:296-300 |
| 关键词 | NAD analog bioorthogonal oxidoreductases chemical biology |
| 产权排序 | 待补充 |
| 通讯作者 | 赵宗保 |
| 合作状况 | 英 |
| 英文摘要 | three new nicotinamide adenine dinucleotide (nad) analogs were synthesized, and their characteristics as cofactors for escherichia coli malic enzyme (me) and its double mutant me l310r/q401c were analyzed. each pair of the nad analog and the double mutant showed good orthogonality to the natural pair of nad and me in terms of catalyzing oxidative decarboxylation of l-malic acid. results indicated that molecular interactions between redox enzyme and cofactor could be further explored to generate new bioorthogonal redox systems. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | unnatural nucleotide specificity ; dinucleotide ; methyltransferase ; receptor |
| 收录类别 | SCI |
| 资助信息 | 1，1 |
| 原文出处 | 300 |
| 语种 | 英语 |
| WOS记录号 | WOS:000314890600005 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119646]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji DeBin,Wang Lei,Liu WuJun,et al. Synthesis of NAD analogs to develop bioorthogonal redox system[J]. science china-chemistry,2013,56(3):296-300. |
| APA | Ji DeBin,Wang Lei,Liu WuJun,Hou ShuHua,&ZongBao, Zhao K..(2013).Synthesis of NAD analogs to develop bioorthogonal redox system.science china-chemistry,56(3),296-300. |
| MLA | Ji DeBin,et al."Synthesis of NAD analogs to develop bioorthogonal redox system".science china-chemistry 56.3(2013):296-300. |
入库方式： OAI收割
来源：大连化学物理研究所
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