Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry
文献类型：期刊论文
| 作者 | Yin, Peiyuan; Xu, Guowang |
| 刊名 | expert review of molecular diagnostics
 |
| 出版日期 | 2013-05-01 |
| 卷号 | 13期号:4页码:339-348 |
| 关键词 | biomarker cancer chromatography mass spectrometry metabolomics translational medicine |
| ISSN号 | 1473-7159 |
| 产权排序 | 待补充 |
| 通讯作者 | 许国旺 |
| 合作状况 | 英 |
| 英文摘要 | early detection is the most effective way to improve the clinical outcome of malignancies. although some tumor markers are now widely used in the clinic, their sensitivity and specificity are still not satisfactory. thus, there is an urgent requirement for the discovery of new tumor markers. by measuring holistic endogenous metabolites, metabolomics can be used for delineating metabolic networks and discovering metabolic markers. chromatography-mass spectrometry is the most widely used tool for metabolomics and has shown great potential for biomarker screening. in this review, the authors summarize: recent advances in the protocols and methodologies of chromatography-mass spectrometry-based metabolomics in the discovery of tumor markers; recently identified tumor metabolic markers for primary liver cancer, gynecologic cancer and genitourinary cancer and their applications; and commonly encountered problems in the translational research of metabolic markers. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 学科主题 | 物理化学 |
| 类目[WOS] | pathology |
| 研究领域[WOS] | pathology |
| 关键词[WOS] | human colorectal-cancer ; differential metabolite discovery ; urinary volatile compounds ; amino-acid profiles ; cell lung-cancer ; hepatocellular-carcinoma ; gas-chromatography ; breast-cancer ; liver-cirrhosis ; bladder-cancer |
| 收录类别 | SCI |
| 资助信息 | 1，1 |
| 原文出处 | 348 |
| 语种 | 英语 |
| WOS记录号 | WOS:000318620900010 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119657]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Peiyuan,Xu, Guowang. Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry[J]. expert review of molecular diagnostics,2013,13(4):339-348. |
| APA | Yin, Peiyuan,&Xu, Guowang.(2013).Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry.expert review of molecular diagnostics,13(4),339-348. |
| MLA | Yin, Peiyuan,et al."Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry".expert review of molecular diagnostics 13.4(2013):339-348. |
入库方式： OAI收割
来源：大连化学物理研究所
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