Effect of plasma components on the stability and permeability of microcapsule
文献类型：期刊论文
| 作者 | Chen, Li1,2; Zhang, Ying1; Li, Shen1,2; Wang, Xiuli1; Li, Na1,2; Wang, Yu1,2; Guo, Xin1; Zhao, Shan1; Yu, Weiting1; Sun, Guangwei1 |
| 刊名 | journal of biomedical materials research part a
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 102期号:7页码:2408-2416 |
| 关键词 | microcapsules bioartificial liver plasma mechanical stability permeability |
| 通讯作者 | 马小军 ; 张英 |
| 产权排序 | 待补充 |
| 合作状况 | 英 |
| 英文摘要 | immobilization of hepatocytes in microcapsules has been a potentially alternative methodology for bioartificial livers (bals). moreover, the stability and permeability are the key parameters of these microcapsules. however, these alginate-based microcapsules are unstable if the surrounding medium disrupts the ionic interactions between alginate and the polycation. as hundreds of components are included in human plasma, the stability and permeability in plasma of microcapsules need to be sufficiently investigated. in the present study, the stability of three kinds of alginate-based microcapsules was evaluated when they were immersed in plasma. our results showed that stability of alginate--poly (l-lysine)-alginate (-apa) microcapsules was well maintained, better than those of alginate-epsilon-poly (l-lysine)-alginate (epsilon-apa) and alginate-chitosan-alginate (aca) microcapsules. also, factors affecting the stability of microcapsules in plasma were analyzed and it showed that heparin was the key factor that affected the stability of -apa microcapsules, whereas heparin and low molecular electrolytes such as hco3- and h2po4-/hpo42- were the factors to epsilon-apa and aca microcapsules. in addition, the permeability evaluation showed no decrease in permeability of microcapsules after incubation in plasma. our study might provide a foundation for the selection and modification of materials for microcapsule-based bal devices. (c) 2013 wiley periodicals, inc. j biomed mater res part a: 102a: 2408-2416, 2014. |
| 学科主题 | 物理化学 |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | engineering, biomedical ; materials science, biomaterials |
| 研究领域[WOS] | engineering ; materials science |
| 关键词[WOS] | fluidized-bed bioreactor ; liver support-systems ; bioartificial liver ; alginate microcapsules ; mechanical-properties ; in-vitro ; hepatocytes ; chitosan ; optimization ; membrane |
| 资助信息 | 1，1 |
| 收录类别 | SCI |
| 原文出处 | 2416 |
| 语种 | 英语 |
| WOS记录号 | WOS:000337570400037 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119706]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Li,Zhang, Ying,Li, Shen,et al. Effect of plasma components on the stability and permeability of microcapsule[J]. journal of biomedical materials research part a,2014,102(7):2408-2416. |
| APA | Chen, Li.,Zhang, Ying.,Li, Shen.,Wang, Xiuli.,Li, Na.,...&Ma, Xiaojun.(2014).Effect of plasma components on the stability and permeability of microcapsule.journal of biomedical materials research part a,102(7),2408-2416. |
| MLA | Chen, Li,et al."Effect of plasma components on the stability and permeability of microcapsule".journal of biomedical materials research part a 102.7(2014):2408-2416. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。