Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases
文献类型：期刊论文
| 作者 | Shen Aijin; Guo Zhimou; Liang Xinmiao |
| 刊名 | progress in chemistry
 |
| 出版日期 | 2014 |
| 卷号 | 26期号:1页码:10-18 |
| 关键词 | hydrophilic interaction liquid chromatography stationary phase polar drugs proteomics metabolomics |
| ISSN号 | 1005-281x |
| 产权排序 | 待补充 |
| 通讯作者 | 梁鑫淼 |
| 合作状况 | 英 |
| 英文摘要 | as an alternative high performance liquid chromatography technology, hydrophilic interaction liquid chromatography (hilic) plays an important role in the separation of highly polar and ionic compounds such as amino acids, carbohydrates, peptides and so on. the development of hilic stationary phases, which are considered as the core of chromatographic technology, is of great importance for the improvement of chromatographic separation selectivity and efficiency, influencing the application and generalization of hilic. to date, a great variety of commercial and academic hilic materials with abundant functional groups have been presented. according to the functional groups of chromatographic materials, the development of silica-based hilic stationary phases including unmodified silica, amino-based, cyano-based, diol-based, amide-based, poly (succinimide) -based, saccharides-based and zwitterion-based stationary phases are reviewed in the present article. meanwhile, the typical applications of hilic stationary phases in polar drugs separation, bioanalysis, proteomics, metabolomics, etc. are included. with increasing diversity of hilic materials, the selection of appropriate hilic stationary phase for the resolution of complex compounds becomes difficult. the development of systematic test samples and methods to access the separation selectivity is of great value for understanding the interaction mechanism of hilic stationary phases. thus, the investigation involving test samples to evaluate separation efficiencies and selectivities in hilic is also reviewed. |
| WOS标题词 | science & technology ; physical sciences |
| 学科主题 | 物理化学 |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | monolithic capillary column ; tandem mass-spectrometry ; light-scattering detection ; mixed-mode ; polar compounds ; cation-exchange ; peptide separation ; charged solutes ; reversed-phase ; silica columns |
| 收录类别 | SCI |
| 资助信息 | 1，1 |
| 原文出处 | 18 |
| 语种 | 英语 |
| WOS记录号 | WOS:000330554500002 |
| 公开日期 | 2014-09-11 |
| 源URL | [http://159.226.238.44/handle/321008/119720]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen Aijin,Guo Zhimou,Liang Xinmiao. Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases[J]. progress in chemistry,2014,26(1):10-18. |
| APA | Shen Aijin,Guo Zhimou,&Liang Xinmiao.(2014).Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases.progress in chemistry,26(1),10-18. |
| MLA | Shen Aijin,et al."Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases".progress in chemistry 26.1(2014):10-18. |
入库方式： OAI收割
来源：大连化学物理研究所
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