Cross Talk Between Vascular Smooth Muscle Cells and Monocytes Through Interleukin-1 beta/Interleukin-18 Signaling Promotes Vein Graft Thickening
文献类型：期刊论文
| 作者 | Li, Ping; Li, Yu-lin1; Li, Zhen-ya2,3; Wu, Yi-na1; Zhang, Cong-cong1; A, Xi1; Wang, Chun-xiao1; Shi, Hong-tao1; Hui, Mi-zhou4; Xie, Bo4 |
| 刊名 | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
 |
| 出版日期 | 2014-09-01 |
| 卷号 | 34期号:9页码:2001-2011 |
| 关键词 | inflammasomes interleukins |
| ISSN号 | 1079-5642 |
| 其他题名 | Arterioscler. Thromb. Vasc. Biol. |
| 中文摘要 | Objective-Interleukin (IL)-1 beta and IL-18 are key proinflammatory cytokines that play important roles in the pathophysiology of vein graft remodeling. However, the mechanism of IL-1 beta/IL-18 production and its role in the development of graft remodeling remain unclear. Approach and Results-IL-1 beta/IL-18 were rapidly expressed in venous interposition grafts. Vascular smooth muscle cell (VSMC) death and monocytic inflammasome activation occurred in grafted veins. Necrotic VSMCs induced the expression of IL-1 beta, IL-18, and other inflammasome-associated proteins in monocytes, which was partially inhibited by their antagonist, recombinant IL-1ra-Fc-IL-18bp. Activated monocytes stimulated proliferation of VSMCs by activating cell growth-related signaling molecules (AKT, STAT3, ERK1/2, and mTOR [AKT/protein kinase B, signal transducer and activator of transcription 3, extracellular signal-regulated kinase 1/2, mammalian target of rapamycin]) and increasing production of platelet-derived growth factor-bb; these effects were suppressed by IL-1ra-Fc-IL-18bp. Activated monocytes also promoted migration of VSMCs, which was independent of IL-1 beta/IL-18 signaling. Importantly, administration of IL-1ra-Fc-IL-18bp inhibited activation of cell growth-related signaling molecules, VSMC proliferation, and vein graft thickening in vivo. Conclusions-Our work identified an interaction among necrotic VSMCs, monocytes, and viable VSMCs through IL-1 beta/IL-18 signaling, which might be exploited as a therapeutic target in vein graft remodeling. |
| 英文摘要 | Objective-Interleukin (IL)-1 beta and IL-18 are key proinflammatory cytokines that play important roles in the pathophysiology of vein graft remodeling. However, the mechanism of IL-1 beta/IL-18 production and its role in the development of graft remodeling remain unclear. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Hematology ; Peripheral Vascular Disease |
| 研究领域[WOS] | Hematology ; Cardiovascular System & Cardiology |
| 关键词[WOS] | NEOINTIMAL FORMATION ; INTERLEUKIN-1 RECEPTOR ; INTIMAL HYPERPLASIA ; GROWTH-FACTORS ; TUNEL ASSAY ; APOPTOSIS ; INFLAMMATION ; ACTIVATION ; EXPRESSION ; DISEASE |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000340881600032 |
| 公开日期 | 2014-09-30 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11447]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Capital Med Univ, Beijing An Zhen Hosp, Dept Vasc Biol, Inst Heart Lung & Blood Vessel Dis, Beijing 100029, Peoples R China 2.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100730, Peoples R China 3.Peking Union Med Coll, Beijing 100021, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing, Peoples R China 5.Baylor Coll Med, Dept Med, Houston, TX 77030 USA |
| 推荐引用方式 GB/T 7714 | Li, Ping,Li, Yu-lin,Li, Zhen-ya,et al. Cross Talk Between Vascular Smooth Muscle Cells and Monocytes Through Interleukin-1 beta/Interleukin-18 Signaling Promotes Vein Graft Thickening[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2014,34(9):2001-2011. |
| APA | Li, Ping.,Li, Yu-lin.,Li, Zhen-ya.,Wu, Yi-na.,Zhang, Cong-cong.,...&Du, Jie.(2014).Cross Talk Between Vascular Smooth Muscle Cells and Monocytes Through Interleukin-1 beta/Interleukin-18 Signaling Promotes Vein Graft Thickening.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,34(9),2001-2011. |
| MLA | Li, Ping,et al."Cross Talk Between Vascular Smooth Muscle Cells and Monocytes Through Interleukin-1 beta/Interleukin-18 Signaling Promotes Vein Graft Thickening".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 34.9(2014):2001-2011. |
入库方式： OAI收割
来源：过程工程研究所
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