Thermo-triggered drug delivery from polymeric micelles of poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) for tumor targeting
文献类型：期刊论文
| 作者 | Sun, Feilong1,2; Wang, Yuxia1; Wei, Yi1; Cheng, Gang2; Ma, Guanghui1 |
| 刊名 | JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 29期号:4页码:301-317 |
| 关键词 | Block copolymer micelle thermo-sensitive controlled drug release tumor targeting hyperthermia thermo-triggered drug delivery |
| ISSN号 | 0883-9115 |
| 其他题名 | J. Bioact. Compat. Polym. |
| 中文摘要 | Novel temperature-sensitive micelles, possessing a core-shell structure, were successfully fabricated and evaluated as possible systems for targeting anticancer drugs to solid tumors. The amphiphilic block copolymer poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) was used to achieve a stimuli-responsive on/off release and spatial specificity. The anticancer drug methotrexate, which is poorly water soluble, was used as the model. Fourier transform-infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, gel-permeation chromatography, and critical micelle concentration were used to evaluate the successful synthesis of block copolymers with a lower critical solution temperature similar to 40 degrees C. Based on transmission electron microscope images, the micelles are spherical particles with narrow size distribution. The thermally triggered release of methotrexate was observed in vitro. Quartz crystal microbalance with dissipation was used to investigate the interactions of the polymeric micelles with bovine serum albumin, to illustrate protein adsorption and cell attachment. Cytotoxicity studies were conducted on Lewis lung carcinoma cells, and the anticancer activity of methotrexate-loaded micelles was significantly enhanced in combination with hyperthermia. The thermo-sensitive characteristics of the micelles make them applicable as smart drug delivery systems, when combined with localized hyperthermia. |
| 英文摘要 | Novel temperature-sensitive micelles, possessing a core-shell structure, were successfully fabricated and evaluated as possible systems for targeting anticancer drugs to solid tumors. The amphiphilic block copolymer poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) was used to achieve a stimuli-responsive on/off release and spatial specificity. The anticancer drug methotrexate, which is poorly water soluble, was used as the model. Fourier transform-infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, gel-permeation chromatography, and critical micelle concentration were used to evaluate the successful synthesis of block copolymers with a lower critical solution temperature similar to 40 degrees C. Based on transmission electron microscope images, the micelles are spherical particles with narrow size distribution. The thermally triggered release of methotrexate was observed in vitro. Quartz crystal microbalance with dissipation was used to investigate the interactions of the polymeric micelles with bovine serum albumin, to illustrate protein adsorption and cell attachment. Cytotoxicity studies were conducted on Lewis lung carcinoma cells, and the anticancer activity of methotrexate-loaded micelles was significantly enhanced in combination with hyperthermia. The thermo-sensitive characteristics of the micelles make them applicable as smart drug delivery systems, when combined with localized hyperthermia. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Materials Science, Biomaterials ; Polymer Science |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Materials Science ; Polymer Science |
| 关键词[WOS] | CORE-SHELL NANOPARTICLES ; IN-VITRO RELEASE ; BLOCK-COPOLYMER ; THERMORESPONSIVE MICELLES ; CELLULAR UPTAKE ; STAR BLOCK ; DOXORUBICIN ; SURFACES ; CELLS ; MICELLIZATION |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000340132800001 |
| 公开日期 | 2014-09-30 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11518]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Shenyang Pharmaceut Univ, Dept Pharmaceut, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Feilong,Wang, Yuxia,Wei, Yi,et al. Thermo-triggered drug delivery from polymeric micelles of poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) for tumor targeting[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2014,29(4):301-317. |
| APA | Sun, Feilong,Wang, Yuxia,Wei, Yi,Cheng, Gang,&Ma, Guanghui.(2014).Thermo-triggered drug delivery from polymeric micelles of poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) for tumor targeting.JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,29(4),301-317. |
| MLA | Sun, Feilong,et al."Thermo-triggered drug delivery from polymeric micelles of poly(N-isopropylacrylamide-co-acrylamide)-b-poly(n-butyl methacrylate) for tumor targeting".JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 29.4(2014):301-317. |
入库方式： OAI收割
来源：过程工程研究所
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