A novel self-lipid antigen targets human T cells against CD1c(+) leukemias
文献类型：期刊论文
| 作者 | Lepore, Marco1,4; de Lalla, Claudia4; Gundimeda, S. Ramanjaneyulu1; Gsellinger, Heiko2; Consonni, Michela4; Garavaglia, Claudio4; Sansano, Sebastiano1; Piccolo, Francesco4; Scelfo, Andrea4; Haeussinger, Daniel2 |
| 刊名 | JOURNAL OF EXPERIMENTAL MEDICINE
 |
| 出版日期 | 2014-06-30 |
| 卷号 | 211期号:7页码:1360-1374 |
| 关键词 | ACUTE MYELOID-LEUKEMIA NKT CELLS MASS-SPECTROMETRY MYCOBACTERIUM-TUBERCULOSIS ELECTROSPRAY-IONIZATION LYSOPHOSPHATIDIC ACID DONOR LYMPHOCYTES IMMUNE-RESPONSES CANCER GLYCOLIPIDS |
| ISSN号 | 0022-1007 |
| 产权排序 | 第十 |
| 通讯作者 | De Libero, G (reprint author), Univ Basel, Univ Hosp Basel, Dept Biomed, CH-4056 Basel, Switzerland. ; lucia_mori@immunol.a-star.edu.sg ; dellabona.paolo@hsr.it ; casorati.giulia@hsr.it ; gennaro.delibero@unibas.ch |
| 英文摘要 | T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects. We report that CD1c self-reactive T cells recognize a novel class of self-lipids, identified as methyl-lysophosphatidic acids (mLPAs), which are accumulated in leukemia cells. Primary acute myeloid and B cell acute leukemia blasts express CD1 molecules. mLPA-specific T cells efficiently kill CD1c(+) acute leukemia cells, poorly recognize nontransformed CD1c-expressing cells, and protect immuno-deficient mice against CD1c+ human leukemia cells. The identification of immunogenic self-lipid antigens accumulated in leukemia cells and the observed leukemia control by lipid-specific T cells in vivo provide a new conceptual framework for leukemia immune surveillance and possible immunotherapy. |
| 学科主题 | Immunology ; Medicine, Research & Experimental |
| 类目[WOS] | Immunology ; Medicine, Research & Experimental |
| 研究领域[WOS] | Immunology ; Research & Experimental Medicine |
| 关键词[WOS] | ACUTE MYELOID-LEUKEMIA ; NKT CELLS ; MASS-SPECTROMETRY ; MYCOBACTERIUM-TUBERCULOSIS ; ELECTROSPRAY-IONIZATION ; LYSOPHOSPHATIDIC ACID ; DONOR LYMPHOCYTES ; IMMUNE-RESPONSES ; CANCER ; GLYCOLIPIDS |
| 收录类别 | SCI |
| 资助信息 | Swiss National Foundation [3100AO-122464/1, Sinergia CRS133-124819]; Association for International Cancer Research; Italian Ministry of Health; Italian Association for Cancer Research (Special Program 5x1000 9965) [AIRC-IG-5804, AIRC-IG-11523]; AIRC Special Program 5x1000 9962; Yunnan High-End Technology Professionals Introduction Program [2010CI117] |
| 语种 | 英语 |
| WOS记录号 | WOS:000338927200009 |
| 公开日期 | 2014-10-11 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18276]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Univ Basel, Univ Hosp Basel, Dept Biomed, CH-4056 Basel, Switzerland 2.Univ Basel, Dept Chem, Nucl Magnet Resonance Lab, CH-4056 Basel, Switzerland 3.Univ Basel, Biozentrum, Dept Biochem, CH-4056 Basel, Switzerland 4.Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Expt Immunol Unit, I-20132 Milan, Italy 5.Ist Sci San Raffaele, Expt Hematol Unit, I-20132 Milan, Italy 6.Ist Sci San Raffaele, Bone Marrow Transplantat Unit, I-20132 Milan, Italy 7.Univ Pavia, Dipartimento Pediat, Immunol Lab, I-27100 Pavia, Italy 8.Fdn IRCCS Policlin San Matteo, I-27100 Pavia, Italy 9.IRCCS Bambino Gesu Hosp, Dept Pediat Hematol Oncol, I-00165 Rome, Italy 10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources We, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lepore, Marco,de Lalla, Claudia,Gundimeda, S. Ramanjaneyulu,et al. A novel self-lipid antigen targets human T cells against CD1c(+) leukemias[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2014,211(7):1360-1374. |
| APA | Lepore, Marco.,de Lalla, Claudia.,Gundimeda, S. Ramanjaneyulu.,Gsellinger, Heiko.,Consonni, Michela.,...&De Libero, Gennaro.(2014).A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.JOURNAL OF EXPERIMENTAL MEDICINE,211(7),1360-1374. |
| MLA | Lepore, Marco,et al."A novel self-lipid antigen targets human T cells against CD1c(+) leukemias".JOURNAL OF EXPERIMENTAL MEDICINE 211.7(2014):1360-1374. |
入库方式： OAI收割
来源：昆明植物研究所
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