Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production
文献类型：期刊论文
| 作者 | Qin, Zhi-Bin1,2,3; Zhang, Jing1,4; Wu, Xing-De1; He, Juan1; Ding, Lin-Fen2,3; Peng, Li-Yan1; Li, Xing-Yao1; Li, Yan1 ; Deng, Liang2,3; Guo, Ya-Dong2,3
|
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2014-06-01 |
| 卷号 | 80期号:8-9页码:703-709 |
| ISSN号 | 0032-0943 |
| 关键词 | Tussilago farfara Asteraceae sesquiterpenoid nitric oxide inhibition |
| 通讯作者 | Schoch, CL (reprint author), Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA. ; schoch2@ncbi.nlm.nih.gov |
| 产权排序 | 第十五 |
| 英文摘要 | Tussilagone (TSL) and its allied sesquiterpenoids were considered as the main active principles of the flower buds of Tussilago farfara, which has been widely used in China as an antitussive herbal medicine. Six new bisabolane-type sesquiterpenoids, tussfararins A-F (1-6), along with 12 known sesquiterpenoids, were isolated from the flower buds of T. farfara. Structures of the new compounds were elucidated by extensive spectroscopic analysis. The biological analysis showed that compounds 1, 3, 6, and 7 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 values of 13.6-24.4 mu M. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | FLOWER BUDS ; CELLS ; L. |
| 资助信息 | National Natural Science Foundation of China [U09326024, 081300]; National Basic Research Program of China (973 Program) [2011CB915503, 2009CB522303] |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000338039800015 |
| 公开日期 | 2014-10-11 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18278]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Zhi-Bin,Zhang, Jing,Wu, Xing-De,et al. Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production[J]. PLANTA MEDICA,2014,80(8-9):703-709. |
| APA | Qin, Zhi-Bin.,Zhang, Jing.,Wu, Xing-De.,He, Juan.,Ding, Lin-Fen.,...&Zhao, Qin-Shi.(2014).Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production.PLANTA MEDICA,80(8-9),703-709. |
| MLA | Qin, Zhi-Bin,et al."Sesquiterpenoids from Tussilago farfara and Their Inhibitory Effects on Nitric Oxide Production".PLANTA MEDICA 80.8-9(2014):703-709. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。