Switch Region for Pathogenic Structural Change in Conformational Disease and Its Prediction
文献类型：期刊论文
| 作者 | Liu X(刘鑫) ; Zhao YP(赵亚溥); Zhao YP(赵亚溥)
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| 刊名 | PLoS One
 |
| 出版日期 | 2010 |
| 卷号 | 5期号:1页码:e8441 |
| 通讯作者邮箱 | yzhao@imech.ac.cn |
| ISSN号 | 1932-6203 |
| 通讯作者 | 赵亚溥 |
| 合作状况 | 其它 |
| 中文摘要 | Many diseases are believed to be related to abnormal protein folding. In the first step of such pathogenic structural changes, misfolding occurs in regions important for the stability of the native structure. This destabilizes the normal protein conformation, while exposing the previously hidden aggregation-prone regions, leading to subsequent errors in the folding pathway. Sites involved in this first stage can be deemed switch regions of the protein, and can represent perfect binding targets for drugs to block the abnormal folding pathway and prevent pathogenic conformational changes. In this study, a prediction algorithm for the switch regions responsible for the start of pathogenic structural changes is introduced. With an accuracy of 94%, this algorithm can successfully find short segments covering sites significant in triggering conformational diseases (CDs) and is the first that can predict switch regions for various CDs. To illustrate its effectiveness in dealing with urgent public health problems, the reason of the increased pathogenicity of H5N1 influenza virus is analyzed; the mechanisms of the pandemic swine-origin 2009 A(H1N1) influenza virus in overcoming species barriers and in infecting large number of potential patients are also suggested. It is shown that the algorithm is a potential tool useful in the study of the pathology of CDs because: (1) it can identify the origin of pathogenic structural conversion with high sensitivity and specificity, and (2) it provides an ideal target for clinical treatment. |
| 学科主题 | 生物力学 |
| 关键词[WOS] | VIRUS NUCLEOPROTEIN GENE; AMYLOID FIBRILS; INFLUENZA-VIRUS; PARKINSONS-DISEASE; SYNTHETIC PEPTIDES; ALPHA-SYNUCLEIN; PRION PROTEIN; IN-VITRO; MUTATIONS; VARIANT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000278099200002 |
| 公开日期 | 2010-05-12 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/33081]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 通讯作者 | Zhao YP(赵亚溥) |
| 推荐引用方式 GB/T 7714 | Liu X,Zhao YP,Zhao YP. Switch Region for Pathogenic Structural Change in Conformational Disease and Its Prediction[J]. PLoS One,2010,5(1):e8441. |
| APA | Liu X,Zhao YP,&赵亚溥.(2010).Switch Region for Pathogenic Structural Change in Conformational Disease and Its Prediction.PLoS One,5(1),e8441. |
| MLA | Liu X,et al."Switch Region for Pathogenic Structural Change in Conformational Disease and Its Prediction".PLoS One 5.1(2010):e8441. |
入库方式： OAI收割
来源：力学研究所
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