Stabilizing to disruptive transition of focal adhesion response to mechanical forces
文献类型：期刊论文
| 作者 | Kong D(孔冬) ; Ji BH(季葆华); Dai LH(戴兰宏)
|
| 刊名 | Journal of Biomechanics
 |
| 出版日期 | 2010-08-18 |
| 卷号 | 43期号:13页码:2524-2529 |
| 通讯作者邮箱 | lhdai@lnm.imech.ac.cn |
| 关键词 | Cell adhesion Focal adhesion Integrin clustering Adhesion growth Cell reorientationIntegrin–ligand bonds |
| ISSN号 | 0021-9290 |
| 通讯作者 | 戴兰宏 |
| 合作状况 | 国内 |
| 中文摘要 | Strong mechanical forces can, obviously, disrupt cell-cell and cell-matrix adhesions, e.g., cyclic uniaxial stretch induces instability of cell adhesion, which then causes the reorientation of cells away from the stretching direction. However, recent experiments also demonstrated the existence of force dependent adhesion growth (rather than dissociation). To provide a quantitative explanation for the two seemingly contradictory phenomena, a microscopic model that includes both integrin-integrin interaction and integrin-ligand interaction is developed at molecular level by treating the focal adhesion as an adhesion cluster. The integrin clustering dynamics and integrin-ligand binding dynamics are then simulated within one unified theoretical frame with Monte Carlo simulation. We find that the focal adhesion will grow when the traction force is higher than a relative small threshold value, and the growth is dominated by the reduction of local chemical potential energy by the traction force. In contrast, the focal adhesion will rupture when the traction force exceeds a second threshold value, and the rupture is dominated by the breaking of integrin-ligand bonds. Consistent with the experiments, these results suggest a force map for various responses of cell adhesion to different scales of mechanical force. PMID: 20542514 |
| 学科主题 | 生物力学; |
| 类目[WOS] | Biophysics ; Engineering, Biomedical |
| 研究领域[WOS] | Biophysics ; Engineering |
| 关键词[WOS] | COUPLED CHEMICAL-REACTIONS ; SMOOTH-MUSCLE-CELLS ; ORIENTATION RESPONSE ; EXTRACELLULAR-MATRIX ; INTEGRIN LIGANDS ; DYNAMICS ; REORIENTATION ; CLUSTERS ; MECHANOSENSITIVITY ; ALIGNMENT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000282545900011 |
| 公开日期 | 2010-09-13 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/42438]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Kong D,Ji BH,Dai LH. Stabilizing to disruptive transition of focal adhesion response to mechanical forces[J]. Journal of Biomechanics,2010,43(13):2524-2529. |
| APA | 孔冬,季葆华,&戴兰宏.(2010).Stabilizing to disruptive transition of focal adhesion response to mechanical forces.Journal of Biomechanics,43(13),2524-2529. |
| MLA | 孔冬,et al."Stabilizing to disruptive transition of focal adhesion response to mechanical forces".Journal of Biomechanics 43.13(2010):2524-2529. |
入库方式： OAI收割
来源：力学研究所
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