Cytotoxic Sesquiterpene Lactones from Aerial Parts of Xanthium sibiricum
文献类型：期刊论文
| 作者 | Wang, Lun ; Wang, Jing ; Li, Fu ; Liu, Xin ; Chen, Bin ; Tang, Ya-Xiong ; Wang, Ming-Kui |
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2013 |
| 卷号 | 79期号:8页码:661-665 |
| 关键词 | Xanthium sibiricum Compositae sesquiterpene lactones xanthanolides cytotoxicity |
| ISSN号 | 0032-0943 |
| 产权排序 | 1 |
| 通讯作者 | Wang, MK (reprint author), Chinese Acad Sci, Chengdu Inst Biol, 9,Sect 4 Renmin South Rd, Chengdu 610041, Peoples R China. |
| 英文摘要 | Chemical investigation of the aerial parts of Xanthium sibiricum led to the isolation of four new xanthanolide-type sesquiterpene lactones, including two xanthanolide dimers, pungiolide D (1) and pungiolide E (2), and two xanthanolide monomers, 8-epi-xanthatin-1 alpha,5 alpha-epoxide (3) and 1 beta-hydroxyl-5 alpha-chloro-8-epi-xanthatin (4), together with four known compounds, pungiolide A (5), 8-epi-xanthatin-1 beta,5 beta-epoxide (6), xanthatin (7), and 11 alpha,13-dihydro-8-epi-xanthatin (8). The structures of these compounds were elucidated on the basis of spectroscopic data analysis. Pungiolide D (1) displayed an unusual structure featuring a 5/5/6-fused tricyclic system in the unit B. Compound 4 was shown to be a rare sesquiterpene lactone containing halogen, and its absolute configuration was determined by X-ray crystallographic analysis. The evaluation of the cytotoxic activities of the isolated new compounds against the SNU387 liver and A-549 lung human cancer cell lines showed that compound 4 possessed significant in vitro cytotoxicity with an IC50 value of 5.1 mu M against SNU387 liver cells. |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319466800009 |
| 公开日期 | 2014-11-21 |
| 源URL | [http://210.75.237.14/handle/351003/24171]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Wang, Lun,Wang, Jing,Li, Fu,et al. Cytotoxic Sesquiterpene Lactones from Aerial Parts of Xanthium sibiricum[J]. PLANTA MEDICA,2013,79(8):661-665. |
| APA | Wang, Lun.,Wang, Jing.,Li, Fu.,Liu, Xin.,Chen, Bin.,...&Wang, Ming-Kui.(2013).Cytotoxic Sesquiterpene Lactones from Aerial Parts of Xanthium sibiricum.PLANTA MEDICA,79(8),661-665. |
| MLA | Wang, Lun,et al."Cytotoxic Sesquiterpene Lactones from Aerial Parts of Xanthium sibiricum".PLANTA MEDICA 79.8(2013):661-665. |
入库方式： OAI收割
来源：成都生物研究所
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