Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum
文献类型：期刊论文
| 作者 | Lin, Y ; Wang, F ; Yang, LJ ; Chun, Z ; Bao, JK ; Zhang, GL |
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 95期号:2013页码:242-251 |
| 关键词 | Dendrobium denneanum Orchidaceae phenanthrene Anti-inflammatory activity iNOS NF-jB MAPKs Cytotoxic RAW264.7 cell |
| ISSN号 | 0031-9422 |
| 产权排序 | 1 |
| 通讯作者 | Zhang, GL |
| 中文摘要 | Cultivated Dendrobium denneanum has been substituted for other endangered Dendrobium species in recent years, but there have been few studies regarding either its chemical constituents or pharmacological effects. In this study, three phenanthrene glycosides, three 9,10-dihydrophenanthrenes, two 9,10-dihydrophenanthrenes glycosides, and four known phenanthrene derivatives, were isolated from the stems of D. denneanum. Their structures were elucidated on the basis of MS and NMR spectroscopic data. Ten compounds were found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated mouse macrophage RAW264.7 cells with IC50 values of 0.7-41.5 mu M, and exhibited no cytotoxicity in RAW264.7, HeLa, or HepG2 cells. Additionally, it was found that 2,5-dihydroxy-4-methoxy-phenanthrene 2-O-beta-D-glucopyranoside, and 5-methoxy-2,4,7,9S-tetrahydroxy-9,10-dihydrophenanthrene suppressed LPS-induced expression of inducible NO synthase (iNOS) inhibited phosphorylation of p38, JNK as well as mitogen-activated protein kinase (MAPK), and inhibitory kappa B-alpha (I kappa B alpha). This indicated that both compounds exert anti-inflammatory effects by inhibiting MAPKs and nuclear factor kappa B (NF-kappa B) pathways. (C) 2013 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology;Plant Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000326901500019 |
| 公开日期 | 2014-11-21 |
| 源URL | [http://210.75.237.14/handle/351003/24206]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Lin, Y,Wang, F,Yang, LJ,et al. Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum[J]. PHYTOCHEMISTRY,2013,95(2013):242-251. |
| APA | Lin, Y,Wang, F,Yang, LJ,Chun, Z,Bao, JK,&Zhang, GL.(2013).Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum.PHYTOCHEMISTRY,95(2013),242-251. |
| MLA | Lin, Y,et al."Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum".PHYTOCHEMISTRY 95.2013(2013):242-251. |
入库方式： OAI收割
来源：成都生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。