Pregnane alkaloids from Sarcococca hookeriana var. digyna
文献类型：期刊论文
| 作者 | Zhang, PZ ; Wang, F ; Yang, LJ ; Zhang, GL |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2013 |
| 卷号 | 89期号:2013页码:143-148 |
| 关键词 | Sarcococca hookeriana var. digyna Steroidal alkaloid Pregnane Estrogen production KGN cell |
| ISSN号 | 0367-326X |
| 产权排序 | 1 |
| 通讯作者 | Zhang, GL |
| 中文摘要 | Fourteen pregnane-type steroidal alkaloids were isolated from the ethanolic extracts of whole Sarcococca hookeriana var. digyna plants. Their structures were elucidated on the basis of spectral data. Three of them were identified as new steroidal alkaloids: (S)-20-(N,N-dimethylamino)-16 alpha,17 alpha-epoxy-3 beta-methoxy-pregn-5-ene (1), (20S)-20-(N,N-dimethylamino)-3 beta-tigloylamino-5 alpha-pregn-11 beta-ol (2), and (20S)-2 alpha-4 beta-bis(acetoxy)-20-(N,N-dimethylamino)-3 beta-tigloylamino-5 alpha-pregnane (3). Some of the isolated compounds showed estrogen biosynthesis-promoting effects in human ovarian granulosa-like KGN cells. The EC50 values for the most effective compounds, vagnine B (6) and funtumafrine C (12), were 71 mu M and 67 mu M, respectively. |
| 学科主题 | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323856500015 |
| 公开日期 | 2014-11-21 |
| 源URL | [http://210.75.237.14/handle/351003/24215]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Zhang, PZ,Wang, F,Yang, LJ,et al. Pregnane alkaloids from Sarcococca hookeriana var. digyna[J]. FITOTERAPIA,2013,89(2013):143-148. |
| APA | Zhang, PZ,Wang, F,Yang, LJ,&Zhang, GL.(2013).Pregnane alkaloids from Sarcococca hookeriana var. digyna.FITOTERAPIA,89(2013),143-148. |
| MLA | Zhang, PZ,et al."Pregnane alkaloids from Sarcococca hookeriana var. digyna".FITOTERAPIA 89.2013(2013):143-148. |
入库方式： OAI收割
来源：成都生物研究所
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