Antiproliferative Activity of Leaf Extract and a Flavonoid Glycoside from Jatropha curcas
文献类型：期刊论文
| 作者 | Lei, L ; Tang, L ; Chen, F ; Xiao, SJ ; Ding, LS |
| 刊名 | LATIN AMERICAN JOURNAL OF PHARMACY
 |
| 出版日期 | 2013 |
| 卷号 | 32期号:6页码:936-939 |
| 关键词 | Antiproliferative A375 A431 Flavonoid glycoside Jatropha curcas Polyphenolic extract Preparative high performance liquid chromatography (PHPLC) |
| ISSN号 | 0326-2383 |
| 产权排序 | 2 |
| 通讯作者 | Chen, F |
| 中文摘要 | In this study, in vitro experiments were conducted on human epidermoid carcinoma A431 and melanoma A375 cells to determine the antiproliferative effect of phenolic-rich extract from Jatropha curcas leaves. Tumor growth inhibition rates on A375 and A431 were 41.2-80% and 43.6-73.7%, respectively, when exposed to 100 mu g/mL of extract. A pure compound from the extract was obtained, identified as isoschaftoside, that showed moderate antiproliferative effect on A375 cells. Our work has demonstrated the strong cytotoxic effect of phenolic-rich extract from Jatropha curcas leaves and is the first time that isosehaftoside has been identified in this plant. This compound was found to have cytotoxic effect, but less pronounced than that of the extract as a whole. This may be indicative of important cytotoxic activities of other compounds within the extract as well as synergic effects among them. |
| 学科主题 | Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000329262000023 |
| 公开日期 | 2014-11-21 |
| 源URL | [http://210.75.237.14/handle/351003/24219]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Lei, L,Tang, L,Chen, F,et al. Antiproliferative Activity of Leaf Extract and a Flavonoid Glycoside from Jatropha curcas[J]. LATIN AMERICAN JOURNAL OF PHARMACY,2013,32(6):936-939. |
| APA | Lei, L,Tang, L,Chen, F,Xiao, SJ,&Ding, LS.(2013).Antiproliferative Activity of Leaf Extract and a Flavonoid Glycoside from Jatropha curcas.LATIN AMERICAN JOURNAL OF PHARMACY,32(6),936-939. |
| MLA | Lei, L,et al."Antiproliferative Activity of Leaf Extract and a Flavonoid Glycoside from Jatropha curcas".LATIN AMERICAN JOURNAL OF PHARMACY 32.6(2013):936-939. |
入库方式： OAI收割
来源：成都生物研究所
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