Loss of Smu1 function de-represses DNA replication and over-activates ATR-dependent replication checkpoint
文献类型：期刊论文
| 作者 | Ren, LF ; Liu, Y ; Guo, LD ; Wang, HB ; Ma, L ; Zeng, M ; Shao, X ; Yang, CL ; Tang, YX ; Wang, L ; Liu, C ; Li, MY |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2013 |
| 卷号 | 436期号:2页码:192-198 |
| 关键词 | DNA replication Smu1 DNA damage Checkpoint |
| ISSN号 | 0006-291X |
| 产权排序 | 5 |
| 通讯作者 | Wang, L ; Liu, C ; Li, MY |
| 中文摘要 | Smu1 is an evolutionarily conserved gene that encodes a member of the WD40-repeat protein family. Disruption of Smu1 function leads to multiple cellular defects including chromosomal instability, aberrant DNA replication and alternative RNA splicing events. In this paper, we show that Smu1 is a chromatin-bound protein that functions as a negative regulator of DNA replication. Knockdown of Smu1 gene expression promotes excessive incorporation of dNTP analogue, implicating the acceleration of DNA synthesis. Smu1-silenced cells show an excessive activation of replication checkpoint in response to ultraviolate (UV) or hydroxyurea treatment, indicating that abnormal stimulation of DNA replication leads to instability of genomic structure. Hence, we propose that Smu1 participates in the protection of genomic integrity by negatively regulating the process of DNA synthesis. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000321601300015 |
| 公开日期 | 2014-11-21 |
| 源URL | [http://210.75.237.14/handle/351003/24227]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Ren, LF,Liu, Y,Guo, LD,et al. Loss of Smu1 function de-represses DNA replication and over-activates ATR-dependent replication checkpoint[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,436(2):192-198. |
| APA | Ren, LF.,Liu, Y.,Guo, LD.,Wang, HB.,Ma, L.,...&Li, MY.(2013).Loss of Smu1 function de-represses DNA replication and over-activates ATR-dependent replication checkpoint.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,436(2),192-198. |
| MLA | Ren, LF,et al."Loss of Smu1 function de-represses DNA replication and over-activates ATR-dependent replication checkpoint".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 436.2(2013):192-198. |
入库方式： OAI收割
来源：成都生物研究所
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