Size-Dependent Toxicity of Nano-C-60 Aggregates: More Sensitive Indication by Apoptosis-Related Bax Translocation in Cultured Human Cell
文献类型：期刊论文
| 作者 | Song, Maoyong ; Yuan, Shaopeng ; Yin, Junfa ; Wang, Xiaoli ; Meng, Zihui ; Wang, Hailin ; Jiang, Guibin |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| 出版日期 | 2012 |
| 卷号 | 46期号:6页码:3457－3464 |
| ISSN号 | 0013-936X |
| 中文摘要 | The toxicity of NPs is not well characterized in terms of their size. In particular, the size-based toxicity of fullerene (C-60) remains an issue because of a lack of C-60 NPs with a well-controlled size. In this work, six fractions of the nano-C-60 aggregates (nC(60)) with different size distribution were prepared by a simple differential centrifugation. By using these nC(60) fractions, we demonstrate the size-dependent inhibition of DNA polymerase and reduced-size enhanced cytotoxicity. Above all, we found that nC(60) NPs with smaller size may have higher toxicity potency. These size-dependent effects were observed at the high exposure doses (4-6 mg/L). Interestingly, at 20-times lower and noncytotoxic doses, the size-dependent effect can be indicated by apoptosis-related fluorescent protein fused Box translocation. Considering the toxicity of NPs is often ignored in the traditional end-point analysis for cytotoxicity when the exposure dose is low, the findings presented here will assist in the evaluation of the size-dependent cytotoxicity and dose-response relationships of toxicity mediated by nC(60) NPs at low doses. |
| WOS记录号 | WOS:000301630200054 |
| 公开日期 | 2014-11-04 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/7766]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Song, Maoyong,Yuan, Shaopeng,Yin, Junfa,et al. Size-Dependent Toxicity of Nano-C-60 Aggregates: More Sensitive Indication by Apoptosis-Related Bax Translocation in Cultured Human Cell[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2012,46(6):3457－3464. |
| APA | Song, Maoyong.,Yuan, Shaopeng.,Yin, Junfa.,Wang, Xiaoli.,Meng, Zihui.,...&Jiang, Guibin.(2012).Size-Dependent Toxicity of Nano-C-60 Aggregates: More Sensitive Indication by Apoptosis-Related Bax Translocation in Cultured Human Cell.ENVIRONMENTAL SCIENCE & TECHNOLOGY,46(6),3457－3464. |
| MLA | Song, Maoyong,et al."Size-Dependent Toxicity of Nano-C-60 Aggregates: More Sensitive Indication by Apoptosis-Related Bax Translocation in Cultured Human Cell".ENVIRONMENTAL SCIENCE & TECHNOLOGY 46.6(2012):3457－3464. |
入库方式： OAI收割
来源：生态环境研究中心
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