The in Vitro Estrogenic Activities of Polyfluorinated Iodine Alkanes
文献类型：期刊论文
| 作者 | Wang, Chang ; Thanh Wang ; Liu, Wei ; Ruan, Ting ; Zhou, Qunfang ; Liu, Jiyan ; Zhang, Aiqian ; Zhao, Bin ; Jiang, Guibin |
| 刊名 | ENVIRONMENTAL HEALTH PERSPECTIVES
 |
| 出版日期 | 2012 |
| 卷号 | 120期号:1页码:119－125 |
| 关键词 | endocrine disruptor estrogenic effects in vitro assay perfluorinated chemicals polyfluorinated iodine alkanes |
| ISSN号 | 0091-6765 |
| 中文摘要 | BACKGROUND: Polyfluorinated iodine alkanes (PFIs) are important intermediates in the synthesis of organic fluoride products. Recently, PFIs have been detected in fluoropolymers as residual raw materials, as well as in the ambient environment. OBJECTIVES: High production volumes and potential environmental releases of PFIs might become a concern, but the exposure risk and toxicity of these chemicals are still unclear. In this study, we investigated the potential estrogenic effects of PFIs. METHODS: We studied the estrogenic effects of fluorinated iodine alkanes (FIAs), fluorinated telomer iodides (FTIs), and fluorinated diiodine alkanes (FDIAs) using the E-screen and MVLN assays and the evaluation of estrogen-responsive genes in MCF-7 cells. RESULTS: FIAs have an iodine atom at one end of the perfluorinated carbon chain. 1-Iodoperfluorohexane (PFHxI) and 1-iodoperfluorooctane (PFOI) promoted the proliferation of MCF-7 cells, induced luciferase activity in MVLN cells, and up-regulated the expression of TFF1 and EGR3. In these assays, other FIAs gave negative responses. FDIAs have an iodine atom at each end of the perfluorinated carbon chain, and all the FDIAs showed estrogenic effects. The estrogenic potencies of FIAs and FDIAs correlate well with the carbon chain length of the chemicals. The optimum chain length for estrogenic effects is six carbons, and then eight and four carbons. All FTIs have a single iodine atom at the end of a partially fluorinated carbon chain. None of the FTIs showed estrogenic effects in the tests. CONCLUSIONS: The estrogenic effects of PFIs are dependent on the structural features of iodine substitution and chain length. This research will be helpful in further understanding the estrogenic effects of perfluorinated compounds. |
| WOS记录号 | WOS:000299650400035 |
| 公开日期 | 2014-11-04 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/7788]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Chang,Thanh Wang,Liu, Wei,et al. The in Vitro Estrogenic Activities of Polyfluorinated Iodine Alkanes[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2012,120(1):119－125. |
| APA | Wang, Chang.,Thanh Wang.,Liu, Wei.,Ruan, Ting.,Zhou, Qunfang.,...&Jiang, Guibin.(2012).The in Vitro Estrogenic Activities of Polyfluorinated Iodine Alkanes.ENVIRONMENTAL HEALTH PERSPECTIVES,120(1),119－125. |
| MLA | Wang, Chang,et al."The in Vitro Estrogenic Activities of Polyfluorinated Iodine Alkanes".ENVIRONMENTAL HEALTH PERSPECTIVES 120.1(2012):119－125. |
入库方式： OAI收割
来源：生态环境研究中心
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