A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer
文献类型：期刊论文
| 作者 | Wang, Lixin ; Zhang, Daoqiang ; Zhang, Changwen ; Zhang, Shuping ; Wang, Zhe ; Qu, Chen ; Liu, Sijin |
| 刊名 | Oncology
 |
| 出版日期 | 2012 |
| 卷号 | 3期号:1页码:119-124 |
| 关键词 | microRNA tumor-initiating cells cancer stem cells breast cancer microarray |
| ISSN号 | 1792-1074 |
| 中文摘要 | microRNAs (miRNAs) are involved in controlling tumor behaviors either as oncogenes or tumor suppressors. To elucidate the role of miRNAs in the regulation of tumor initiation, we delineated the microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer. A group of miRNAs were differentially expressed in MDA-MB-231 and SUM1315 cells (with a high proportion of breast cancer tumor-initiating cells, CD44(+)CD24(-/low) subpopulation) compared to MCF-7 cells (only a small proportion of CD44(+)CD24(-/low) cells). Among the differentially expressed miRNAs common to MDA-MB-231 and SUM1315, approximately 46% of them are suggested to regulate the 'stemness' of stem cells or progenitor cells. Taken together, these findings suggested that miRNAs contribute to the maintenance of tumor-initiating properties and indicate the potential value of the miRNA expression signature in characterizing or predicting the features (including metastasis) of breast cancer. |
| WOS记录号 | WOS:000298124700022 |
| 公开日期 | 2014-11-27 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/8024]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang, Lixin,Zhang, Daoqiang,Zhang, Changwen,et al. A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer[J]. Oncology,2012,3(1):119-124. |
| APA | Wang, Lixin.,Zhang, Daoqiang.,Zhang, Changwen.,Zhang, Shuping.,Wang, Zhe.,...&Liu, Sijin.(2012).A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer.Oncology,3(1),119-124. |
| MLA | Wang, Lixin,et al."A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer".Oncology 3.1(2012):119-124. |
入库方式： OAI收割
来源：生态环境研究中心
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