MutL associates with Escherichia coli RecA and inhibits its ATPase activity
文献类型：期刊论文
| 作者 | Zhang, Min ; Zhou, Ying ; Li, Tao ; Wang, Hailin ; Cheng, Fang ; Zhou, Yafeng ; Bi, Lijun ; Zhang, Xian-En |
| 刊名 | Biochemistry & Molecular Biology; Biophysics
 |
| 出版日期 | 2012 |
| 卷号 | 517期号:2页码:98-103 |
| 关键词 | RecA MutL Homologous recombination Protein interaction |
| ISSN号 | 0003-9861 |
| 中文摘要 | Different DNA repair systems are known to cooperate to deal with DNA damage. However, the regulatory role of the cross-talk between these pathways is unclear. Here, we have shown that MutL, an essential component of mismatch repair, is a RecA-interacting protein, and that its highly conserved N-terminal domain is sufficient for this interaction. Surface plasmon resonance and capillary electrophoresis analyses revealed that MutL has little effect on RecA-ssDNA filament formation, but dose down-regulate the ATPase activity of RecA. Our findings identify a new role for MutL, and suggest its regulatory role in homologous recombination. (C) 2011 Published by Elsevier Inc. |
| WOS记录号 | WOS:000299146000002 |
| 公开日期 | 2014-11-27 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/8069]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Min,Zhou, Ying,Li, Tao,et al. MutL associates with Escherichia coli RecA and inhibits its ATPase activity[J]. Biochemistry & Molecular Biology; Biophysics,2012,517(2):98-103. |
| APA | Zhang, Min.,Zhou, Ying.,Li, Tao.,Wang, Hailin.,Cheng, Fang.,...&Zhang, Xian-En.(2012).MutL associates with Escherichia coli RecA and inhibits its ATPase activity.Biochemistry & Molecular Biology; Biophysics,517(2),98-103. |
| MLA | Zhang, Min,et al."MutL associates with Escherichia coli RecA and inhibits its ATPase activity".Biochemistry & Molecular Biology; Biophysics 517.2(2012):98-103. |
入库方式： OAI收割
来源：生态环境研究中心
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