Structural Evidence of Perfluorooctane Sulfonate Transport by Human Serum Albumin
文献类型：期刊论文
| 作者 | Luo, Zhipu ; Shi, Xiaoli ; Hu, Qin ; Zhao, Bin ; Huang, Mingdong |
| 刊名 | Pharmacology & Pharmacy; Chemistry; Toxicology
 |
| 出版日期 | 2012 |
| 卷号 | 25期号:5页码:990-992 |
| ISSN号 | 0893-228X |
| 中文摘要 | Perfluorooctane sulfonate (PFOS) is a man-made fluorosurfactant and globally persistent organic pollutant. PFOS is mainly distributed in blood with a long half-life for elimination. PFOS was found mainly bound to human serum albumin (HSA) in plasma, the most abundant protein in human blood plasma, which transports a variety of endogenous and exogenous ligands. However, the structural basis of such binding remains unclear. Here, we report the crystal structure of the HSA-PFOS complex and show that PFOS binds to HSA at a molar ratio of 2:1. In addition, PFOS binding renders the HSA structure more compact. Our results provide a structural mechanism to understand the retention of surfactants in human serum. |
| WOS记录号 | WOS:000304235000002 |
| 公开日期 | 2014-11-27 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/8079]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Luo, Zhipu,Shi, Xiaoli,Hu, Qin,et al. Structural Evidence of Perfluorooctane Sulfonate Transport by Human Serum Albumin[J]. Pharmacology & Pharmacy; Chemistry; Toxicology,2012,25(5):990-992. |
| APA | Luo, Zhipu,Shi, Xiaoli,Hu, Qin,Zhao, Bin,&Huang, Mingdong.(2012).Structural Evidence of Perfluorooctane Sulfonate Transport by Human Serum Albumin.Pharmacology & Pharmacy; Chemistry; Toxicology,25(5),990-992. |
| MLA | Luo, Zhipu,et al."Structural Evidence of Perfluorooctane Sulfonate Transport by Human Serum Albumin".Pharmacology & Pharmacy; Chemistry; Toxicology 25.5(2012):990-992. |
入库方式： OAI收割
来源：生态环境研究中心
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