Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells
文献类型：期刊论文
| 作者 | Maiwulanjiang, Maitinuer ; Zhu, Kevin Y.; Chen, Jianping; Miernisha, Abudureyimu; Xu, Sherry L.; Du, Crystal Y. Q.; Lau, Kitty K. M.; Choi, Roy C. Y.; Dong, Tina T. X.; Aisa, Haji A.
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| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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| 出版日期 | 2013 |
| 卷号 | 2013期号:2 |
| ISSN号 | 1741-427X |
| 中文摘要 | Song Bu Li decoction (SBL) is a traditional Uyghur medicinal herbal preparation, containing Nardostachyos Radix et Rhizoma. Recently, SBL is being used to treat neurological disorders (insomnia and neurasthenia) and heart disorders (arrhythmia and palpitation). Although this herbal extract has been used for many years, there is no scientific basis about its effectiveness. Here, we aimed to evaluate the protective and differentiating activities of SBL in cultured PC12 cells. The pretreatment of SBL protected the cell against tBHP-induced cell death in a dose-dependent manner. In parallel, SBL suppressed intracellular reactive oxygen species (ROS) formation. The transcriptional activity of antioxidant response element (ARE), as well as the key antioxidative stress proteins, was induced in dose-dependent manner by SBL in the cultures. In cultured PC12 cells, the expression of neurofilament, a protein marker for neuronal differentiation, was markedly induced by applied herbal extract. Moreover, the nerve growth factor( NGF-) induced neurite outgrowth in cultured PC12 cells was significantly potentiated by the cotreatment of SBL. In accord, the expression of neurofilament was increased in the treatment of SBL. These results therefore suggested a possible role of SBL by its effect on neuron differentiation and protection against oxidative stress. |
| 收录类别 | SCI |
| 资助信息 | Hong Kong Research Grants Council Theme-based Research SchemeGRF Foundation of The Awareness of Nature |
| 公开日期 | 2014-11-11 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/3911]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China;Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China;Chinese Acad Sci, Xinjiang Key Lab Plant Resources & Nat Prod Chem, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Maiwulanjiang, Maitinuer,Zhu, Kevin Y.,Chen, Jianping,et al. Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,2013(2). |
| APA | Maiwulanjiang, Maitinuer.,Zhu, Kevin Y..,Chen, Jianping.,Miernisha, Abudureyimu.,Xu, Sherry L..,...&Tsim, Karl W. K..(2013).Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013(2). |
| MLA | Maiwulanjiang, Maitinuer,et al."Song Bu Li Decoction, a Traditional Uyghur Medicine, Protects Cell Death by Regulation of Oxidative Stress and Differentiation in Cultured PC12 Cells".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2013.2(2013). |
入库方式： OAI收割
来源：新疆理化技术研究所
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