Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip
文献类型：期刊论文
| 作者 | Wang CL; Li JQ ; Li HW; Jin G(靳刚); Wang ZH(王战会); Meng YH(孟永宏); Xiu RJ
|
| 刊名 | Artificial Cells Blood Substitutes and Biotechnology
 |
| 出版日期 | 2009 |
| 卷号 | 37期号:4页码:183-186 |
| 通讯作者邮箱 | wangchlcams@yahoo.com.cn |
| ISSN号 | 1073-1199 |
| 关键词 | Soluble Tie-2 Acute Myocardial Infarction Elisa Optical Protein-Chip Imaging Ellipsometry Imaging Ellipsometry Tyrosine Kinase Tek |
| 通讯作者 | Wang CL |
| 合作状况 | 国内 |
| 中文摘要 | The Tie-2 receptor has been shown to play a role in angiogenesis in atherosclerosis. The conventional method assaying the level of soluble Tie-2 (sTie-2) was ELISA. However, this method has some disadvantages. The aims of this research are to establish a more simple detection method, the optical protein-chip based on imaging ellipsomtry (OPC-IE) applying to Tie-2 assay. The sTie-2 biosensor surface on silicon wafer was prepared first, and then serum levels of sTie-2 in 38 patients with AMI were measured on admission (day 1), day 2, day 3 and day 7 after onset of chest pain and 41 healthy controls by ELISA and OPC-IE in parallel. Median level of sTie-2 increased significantly in the AMI patients when compared with the controls. Statistics showed there was a significant correlation in sTie-2 results between the two methods (r=0.923, P0.01). The result of this study showed that the level of sTie-2 increased in AMI, and OPC-IE assay was a fast, reliable, and convenient technique to measure sTie-2 in serum. |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Engineering ; Materials Science |
| 关键词[WOS] | IMAGING ELLIPSOMETRY ; TYROSINE KINASE ; TEK |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1080/10731190903043416 |
| 语种 | 英语 |
| WOS记录号 | WOS:000267835500007 |
| 公开日期 | 2009-08-03 ; 2009-10-09 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/26690]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 推荐引用方式 GB/T 7714 | Wang CL,Li JQ,Li HW,et al. Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip[J]. Artificial Cells Blood Substitutes and Biotechnology,2009,37(4):183-186. |
| APA | Wang CL.,Li JQ.,Li HW.,Jin G.,Wang ZH.,...&Xiu RJ.(2009).Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip.Artificial Cells Blood Substitutes and Biotechnology,37(4),183-186. |
| MLA | Wang CL,et al."Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip".Artificial Cells Blood Substitutes and Biotechnology 37.4(2009):183-186. |
入库方式： OAI收割
来源：力学研究所
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