Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera
文献类型：期刊论文
| 作者 | Chen, Qi-Bin; Xin, Xue-Lei ; Yang, Yi; Lee, Shoei-Sheng; Aisa, H. A.
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2014 |
| 卷号 | 77期号:4页码:807-812 |
| ISSN号 | 0163-3864 |
| 通讯作者 | Aisa, HA |
| 中文摘要 | Three norditerpenoid alkaloids, nigelladines A-C (1-3), and one pyrroloquinoline alkaloid, nigellaquinomine (4), all possessing new skeletons with highly conjugated systems, were isolated from Nigella glandulifera. The 8aS-configuration for 1 and 2 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. These alkaloids exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity but are devoid of cytotoxicity against the A431 cell line at 100 mu M. |
| 资助信息 | National Science Fund for Distinguished Young Scholars；National Natural Science Foundation of China；Projects of International Science & Techology Cooperation of the Xinjiang Uyghur Autonomous Region |
| 收录类别 | SCI |
| 公开日期 | 2014-11-11 |
| 源URL | [http://ir.xjipc.cas.cn/handle/365002/3794]  |
| 专题 | 新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室 新疆理化技术研究所_资源化学研究室 |
| 作者单位 | Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100039, Peoples R China;Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10051, Taiwan |
| 推荐引用方式 GB/T 7714 | Chen, Qi-Bin,Xin, Xue-Lei,Yang, Yi,et al. Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):807-812. |
| APA | Chen, Qi-Bin,Xin, Xue-Lei,Yang, Yi,Lee, Shoei-Sheng,&Aisa, H. A..(2014).Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera.JOURNAL OF NATURAL PRODUCTS,77(4),807-812. |
| MLA | Chen, Qi-Bin,et al."Highly Conjugated Norditerpenoid and Pyrroloquinoline Alkaloids with Potent PTP1B Inhibitory Activity from Nigella glandulifera".JOURNAL OF NATURAL PRODUCTS 77.4(2014):807-812. |
入库方式： OAI收割
来源：新疆理化技术研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。