Mechanistic studies for monodisperse exenatide-loaded PLGA microspheres prepared by different methods based on SPG membrane emulsification
文献类型：期刊论文
| 作者 | Qi, Feng1,2; Wu, Jie1; Yang, Tingyuan1; Ma, Guanghui1,3; Su, Zhiguo1,3 |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2014-10-01 |
| 卷号 | 10期号:10页码:4247-4256 |
| 关键词 | PLGA Controlled release Exenatide SPG membrane emulsification Microsphere |
| ISSN号 | 1742-7061 |
| 其他题名 | Acta Biomater. |
| 中文摘要 | Poly(DL-lactic-co-glycolic acid) (PLGA) microspheres have been widely prepared by many methods, including solvent evaporation, solvent extraction and the co-solvent method. However, very few studies have compared the properties of microspheres fabricated by these methods. This is partly because the broad size distribution of the resultant particles severely complicates the analysis and affects the reliability of the comparison. To this end, uniform-sized PLGA microspheres have been prepared by Shirasu porous glass premix membrane emulsification and used to encapsulate exenatide, a drug for treating Type 2 diabetes. Based on this technique, the influences on the properties of microspheres fabricated by the aforementioned three methods were intensively investigated, including in vitro release, degradation and pharmacology. We found that these microspheres presented totally different release behaviors in vitro and in vivo, but exhibited a similar trend of PLGA degradation. Moreover, the internal structural evolution visually demonstrated these release behaviors. We selected for further examination the microsphere prepared by solvent evaporation because of its constant release rate, and explored its pharmacodynamics, histology, etc., in more detail. This microsphere when injected once showed equivalent efficacy to that of twice-daily injections of exenatide with no inflammatory response. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| 英文摘要 | Poly(DL-lactic-co-glycolic acid) (PLGA) microspheres have been widely prepared by many methods, including solvent evaporation, solvent extraction and the co-solvent method. However, very few studies have compared the properties of microspheres fabricated by these methods. This is partly because the broad size distribution of the resultant particles severely complicates the analysis and affects the reliability of the comparison. To this end, uniform-sized PLGA microspheres have been prepared by Shirasu porous glass premix membrane emulsification and used to encapsulate exenatide, a drug for treating Type 2 diabetes. Based on this technique, the influences on the properties of microspheres fabricated by the aforementioned three methods were intensively investigated, including in vitro release, degradation and pharmacology. We found that these microspheres presented totally different release behaviors in vitro and in vivo, but exhibited a similar trend of PLGA degradation. Moreover, the internal structural evolution visually demonstrated these release behaviors. We selected for further examination the microsphere prepared by solvent evaporation because of its constant release rate, and explored its pharmacodynamics, histology, etc., in more detail. This microsphere when injected once showed equivalent efficacy to that of twice-daily injections of exenatide with no inflammatory response. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | POLY(LACTIC-CO-GLYCOLIC ACID) MICROSPHERES ; IN-VITRO ; BIODEGRADABLE MICROPARTICLES ; SUSTAINED-RELEASE ; PLA NANOPARTICLES ; PROTEIN DELIVERY ; DRUG-RELEASE ; MORPHOLOGY ; DEGRADATION ; EMULSION |
| 收录类别 | SCI |
| 原文出处 | |
| 语种 | 英语 |
| WOS记录号 | WOS:000342523800019 |
| 公开日期 | 2014-11-02 |
| 版本 | 出版稿 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/11652]  |
| 专题 | 过程工程研究所_研究所（批量导入） |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Biochem Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Feng,Wu, Jie,Yang, Tingyuan,et al. Mechanistic studies for monodisperse exenatide-loaded PLGA microspheres prepared by different methods based on SPG membrane emulsification[J]. ACTA BIOMATERIALIA,2014,10(10):4247-4256. |
| APA | Qi, Feng,Wu, Jie,Yang, Tingyuan,Ma, Guanghui,&Su, Zhiguo.(2014).Mechanistic studies for monodisperse exenatide-loaded PLGA microspheres prepared by different methods based on SPG membrane emulsification.ACTA BIOMATERIALIA,10(10),4247-4256. |
| MLA | Qi, Feng,et al."Mechanistic studies for monodisperse exenatide-loaded PLGA microspheres prepared by different methods based on SPG membrane emulsification".ACTA BIOMATERIALIA 10.10(2014):4247-4256. |
入库方式： OAI收割
来源：过程工程研究所
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