Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17
文献类型：期刊论文
| 作者 | Fang, W ; Lin, XP ; Zhou, XF ; Wan, JT ; Lu, X ; Yang, B ; Ai, W ; Lin, J ; Zhang, TY ; Tu, ZC ; Liu, YH |
| 刊名 | MEDCHEMCOMM
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:6页码:701-705 |
| ISSN号 | 2040-2503 |
| 通讯作者 | xfzhou@scsio.ac.cn ; yonghongliu@scsio.ac.cn |
| 中文摘要 | Nitrobenzoyl sesquiterpenoids are rare in natural sources, and fungi Aspergillus species are the only sources of them. A new nitrobenzoyl sesquiterpenoid, 6 beta, 9 alpha-dihydroxy-14-p-nitrobenzoylcinnamolide (1), and a known analogue, insulicolide A (2), were isolated from extracts of the culture of marine-derived fungus Aspergillus ochraceus Jcma1F17, which was identified by morphological and ITS phylogenetic analyses. The structures were determined by NMR, MS, CD, and optical rotation analyses. Both nitrobenzoyl sesquiterpenoids displayed significant cytotoxicities against 10 cancer cell lines, and the new one (1) also showed antiviral activities against H3N2 and EV71. This is the first time that nitrobenzoyl sesquiterpenoids from A. ochraceus have been reported. |
| 学科主题 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [41376162, 21302198, 31270402, 21172230]; National High Technology Research and Development Program of China [2012AA092104]; National Key Basic Research Program of China (973)'s project [2010CB833800, 2011CB915503]; Guangdong Natural Science Foundation [S2013010012474]; Innovative Development and Regional Demonstration Project of Guangdong Marine Economy [GD2012-D01-001] |
| 原文出处 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000336843000002 |
| 公开日期 | 2014-12-11 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10662]  |
| 专题 | 南海海洋研究所_广东省海洋药物重点实验室 |
| 推荐引用方式 GB/T 7714 | Fang, W,Lin, XP,Zhou, XF,et al. Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17[J]. MEDCHEMCOMM,2014,5(6):701-705. |
| APA | Fang, W.,Lin, XP.,Zhou, XF.,Wan, JT.,Lu, X.,...&Liu, YH.(2014).Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17.MEDCHEMCOMM,5(6),701-705. |
| MLA | Fang, W,et al."Cytotoxic and antiviral nitrobenzoyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17".MEDCHEMCOMM 5.6(2014):701-705. |
入库方式： OAI收割
来源：南海海洋研究所
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