Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis
文献类型：期刊论文
| 作者 | Chen, YL ; Zhang, WJ ; Zhu, YG ; Zhang, QB ; Tian, XP ; Zhang, S ; Zhang, CS |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 16期号:3页码:736-739 |
| ISSN号 | 1523-7060 |
| 通讯作者 | zhuyiguang2003@163.com ; czhang2006@gmail.com |
| 中文摘要 | The piericidin A1 (1) gene cluster was identified from the deep-sea derived Streptomyces sp. SCSIO 03032. Our in vivo and in vitro experiments verified PieE as a 4'-hydroxylase and PieB2 as a 4'-O-methyltransferase, allowing the elucidation of the post-PKS modification steps involved in 1 biosynthesis. In addition, the shunt metabolite piericidin El (7) was identified as a novel analogue featuring a C-2/C-3 epoxy ring. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| 资助信息 | MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KSCX2-EW-G-12]; NSFC [31125001, 31290233]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002] |
| 原文出处 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000331163900025 |
| 公开日期 | 2014-12-11 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10663]  |
| 专题 | 南海海洋研究所_广东省海洋药物重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, YL,Zhang, WJ,Zhu, YG,et al. Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis[J]. ORGANIC LETTERS,2014,16(3):736-739. |
| APA | Chen, YL.,Zhang, WJ.,Zhu, YG.,Zhang, QB.,Tian, XP.,...&Zhang, CS.(2014).Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis.ORGANIC LETTERS,16(3),736-739. |
| MLA | Chen, YL,et al."Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis".ORGANIC LETTERS 16.3(2014):736-739. |
入库方式： OAI收割
来源：南海海洋研究所
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