Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase
文献类型：期刊论文
| 作者 | Ji, CT ; Chen, Q ; Li, QL ; Huang, HB ; Song, YX ; Ma, JY ; Ju, JH |
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 55期号:35页码:4901-4904 |
| 关键词 | Amide synthetase beta-Carboline McbA Chemoenzymatic synthesis |
| ISSN号 | 0040-4039 |
| 通讯作者 | jju@scsio.ac.cn |
| 中文摘要 | McbA was characterized in vitro as a novel amide synthetase in the marinacarbolines A-D biosynthetic pathway, catalyzing amide bond formation between 1-acetyl-3-carboxy-beta-carboline (la) and substituted-beta-phenethylamines (1b, 213, 3b) and tryptamine (4b) in an ATP-dependent manner. Enzyme kinetic analyses highlight beta-phenethylamine as the most suitable amine donor. McbA showed broad substrate compatibility with substituted amines; 10 new beta-carboline analogues were chemoenzymatically generated. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| 资助信息 | MOST [2012AA092104, 2010CB833805]; CAS [XDA11030403, KGZD-EW-606] |
| 原文出处 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000340985800013 |
| 公开日期 | 2014-12-11 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10396]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Ji, CT,Chen, Q,Li, QL,et al. Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase[J]. TETRAHEDRON LETTERS,2014,55(35):4901-4904. |
| APA | Ji, CT.,Chen, Q.,Li, QL.,Huang, HB.,Song, YX.,...&Ju, JH.(2014).Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase.TETRAHEDRON LETTERS,55(35),4901-4904. |
| MLA | Ji, CT,et al."Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase".TETRAHEDRON LETTERS 55.35(2014):4901-4904. |
入库方式： OAI收割
来源：南海海洋研究所
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