Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation
文献类型：期刊论文
| 作者 | Fu, P ; Zhu, YG ; Mei, XG ; Wang, Y ; Jia, HJ ; Zhang, CS ; Zhu, WM |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 16期号:16页码:4264-4267 |
| ISSN号 | 1523-7060 |
| 通讯作者 | czhang2006@gmail.com ; weimingzhu@ouc.edu.cn |
| 中文摘要 | Inactivation of the O-methyltransferase gene crmM of Actinoalloteichus cyanogriseus WH1-2216-6 led to a mutant that produced three new acyclic bipyridine glycosides, cyanogrisides E-G (1-3). Further chemical analysis of the wild strain yielded 1 and another new analogue, cyanogriside H (4). Compounds 1-4 possess a skeleton consisting of a 2,2'-bipyridine and a D-quinovose or L-rhamnose sugar moiety. Cyanogriside G (3) was considered to be a key biosynthetic intermediate of the cyclic bipyridine glycosides cyanogrisides A-D. Compounds 2 and 3 showed cytotoxicities against HCTI16 and HL-60 cells, and compounds 1 and 4 were cytotoxic on K562 cells. |
| 学科主题 | Chemistry |
| 资助信息 | NSFC [21172204, 41376148, 81373298, 31070045, 31125001]; 973 Program of China [2010CB833800]; Public Science and Technology Research Funds Projects of Ocean [201405038]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-002] |
| 收录类别 | SCI |
| 原文出处 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000340517200053 |
| 公开日期 | 2014-12-11 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10402]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Fu, P,Zhu, YG,Mei, XG,et al. Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation[J]. ORGANIC LETTERS,2014,16(16):4264-4267. |
| APA | Fu, P.,Zhu, YG.,Mei, XG.,Wang, Y.,Jia, HJ.,...&Zhu, WM.(2014).Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation.ORGANIC LETTERS,16(16),4264-4267. |
| MLA | Fu, P,et al."Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation".ORGANIC LETTERS 16.16(2014):4264-4267. |
入库方式： OAI收割
来源：南海海洋研究所
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