Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria
文献类型：期刊论文
| 作者 | Song, YX ; Li, QL ; Liu, X ; Chen, YC ; Zhang, Y ; Sun, AJ ; Zhang, WM ; Zhang, JR ; Ju, JH |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2014 |
| 卷号 | 77期号:8页码:1937-1941 |
| ISSN号 | 0163-3864 |
| 通讯作者 | jju@scsio.ac.cn |
| 中文摘要 | Three new cyclohexapeptides, desotamides B-D (2-4), and the known desotamide (1) were isolated from marine microbe Streptomyces scopuliridis SCSIO ZJ46. The sequences and absolute configurations of 2-4 were elucidated on the basis of high-resolution spectroscopic data, Marfey's method, and chiral-phase HPLC data. Desotamide C (3) contains a unique N-formyl-kynurenine residue, whereas 4 lacks formylation at the same site. Compounds 1 and 2 displayed notable antibacterial activities against strains of Streptococcus pnuemoniae, Staphylococcus aureus, and methicillin-resistant Staphylococcus epidermidis (MRSE), and structure activity relationship studies revealed the indispensability of the Tip component for antibacterial activity within this new scaffold. |
| 学科主题 | Plant Sciences ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [41206135]; National High Technology Research and Development Program of China [2012AA092104]; Chinese Academy of Sciences [XDA11030403, SQ201119]; Marine Economic Demonstration Project [GD2012-D01-001] |
| 原文出处 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000340861800023 |
| 公开日期 | 2014-12-11 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10412]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Song, YX,Li, QL,Liu, X,et al. Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(8):1937-1941. |
| APA | Song, YX.,Li, QL.,Liu, X.,Chen, YC.,Zhang, Y.,...&Ju, JH.(2014).Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria.JOURNAL OF NATURAL PRODUCTS,77(8),1937-1941. |
| MLA | Song, YX,et al."Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria".JOURNAL OF NATURAL PRODUCTS 77.8(2014):1937-1941. |
入库方式： OAI收割
来源：南海海洋研究所
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