Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship
文献类型：期刊论文
| 作者 | Bao, J ; Luo, JF ; Qin, XC ; Xu, XY ; Zhang, XY ; Tu, ZC ; Qi, SH |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 24期号:11页码:2433-2436 |
| 关键词 | Penicillium oxalicum Dihydrothiophene-condensed chromones Cytotoxicity Structure-bioactivity relationship |
| ISSN号 | 0960-894X |
| 通讯作者 | tu_zhengchao@gibh.ac.cn ; shuhuaqi@scsio.ac.cn |
| 中文摘要 | Four dihydrothiophene-condensed chromones including two new compounds oxalicumones D-E (1-2) and known oxalicumones A-B (3-4), along with five other known chromones were isolated from a culture broth of the marine gorgonian-associated fungus Penicillium oxalicum SCSGAF 0023. The structures of 1-2 were elucidated by spectroscopic analysis. Eleven derivatives 3a-3i and 4a-4b were obtained from the acylation of 3 and 4, respectively. Compounds 1-4, 3a-3e, 3g-3h, and 4b showed significant cytotoxicity against several carcinoma cell lines with IC50 <= 10 mu M. And their structure-bioactivity relationship was discussed. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy ; Chemistry |
| 收录类别 | SCI |
| 资助信息 | National Marine Public Welfare Research Project of China [201305017]; National Natural Science Foundation of China [41376160]; National Basic Research Program of China (973 Program) [2010CB833803]; National High Technology Research and Development Program of China (863 Program) [2012AA092104] |
| 原文出处 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000335518300008 |
| 公开日期 | 2014-12-11 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10435]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Bao, J,Luo, JF,Qin, XC,et al. Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(11):2433-2436. |
| APA | Bao, J.,Luo, JF.,Qin, XC.,Xu, XY.,Zhang, XY.,...&Qi, SH.(2014).Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(11),2433-2436. |
| MLA | Bao, J,et al."Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.11(2014):2433-2436. |
入库方式： OAI收割
来源：南海海洋研究所
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