Mechanistic Insights into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis
文献类型：期刊论文
| 作者 | Zhang, GT ; Zhang, WJ ; Zhang, QB ; Shi, T ; Ma, L ; Zhu, YG ; Li, SM ; Zhang, HB ; Zhao, YL ; Shi, R ; Zhang, CS |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2014 |
| 卷号 | 53期号:19页码:4840-4844 |
| ISSN号 | 1433-7851 |
| 关键词 | biosynthesis heterologous expression ikarugamycin polycyclic tetramate macrolactams reductive cyclization |
| 通讯作者 | czhang2006@gmail.com |
| 中文摘要 | Ikarugamycin is a member of the polycyclic tetramate macrolactams (PTMs) family of natural products with diverse biological activities. The biochemical mechanisms for the formation of polycyclic ring systems in PTMs remain elusive. The enzymatic mechanism of constructing an inner five-membered ring in ikarugamycin is reported. A three-gene-cassette ikaABC from the marine-derived Streptomyces sp. ZJ306 is sufficient for conferring ikarugamycin production in a heterologous host. IkaC catalyzes a reductive cyclization reaction to form the inner five-membered ring by a Michael addition-like reaction. This study provides the first biochemical evidence for polycycle formation in PTMs and suggests a reductive cyclization strategy which may be potentially applicable in general to the corresponding ring formation in other PTMs. |
| 学科主题 | Chemistry |
| 资助信息 | National Natural Science Foundation of China [31125001, 21377085]; Ministry of Science and Technology of China [2010CB833805, 2012AA092104]; Chinese Academy of Sciences [XDA11030403]; Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002] |
| 收录类别 | SCI |
| 原文出处 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000335202700013 |
| 公开日期 | 2014-12-11 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10440]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, GT,Zhang, WJ,Zhang, QB,et al. Mechanistic Insights into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(19):4840-4844. |
| APA | Zhang, GT.,Zhang, WJ.,Zhang, QB.,Shi, T.,Ma, L.,...&Zhang, CS.(2014).Mechanistic Insights into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(19),4840-4844. |
| MLA | Zhang, GT,et al."Mechanistic Insights into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.19(2014):4840-4844. |
入库方式： OAI收割
来源：南海海洋研究所
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