Marine Compound Catunaregin Inhibits Angiogenesis through the Modulation of Phosphorylation of Akt and eNOS in vivo and in vitro
文献类型：期刊论文
| 作者 | Liu, JX ; Luo, MQ ; Xia, M ; Wu, Q ; Long, SM ; Hu, YH ; Gao, GC ; Yao, XL ; He, MA ; Su, HX ; Luo, XM ; Yao, SZ |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2014 |
| 卷号 | 12期号:5页码:2790-2801 |
| ISSN号 | 1660-3397 |
| 关键词 | anti-angiogenesis catunaregin VEGF zebrafish HUVECs |
| 通讯作者 | liujxiu@mail.sysu.edu.cn ; zhanglmq@sina.com ; xiameng25@163.com ; wuqi@medmail.com.cn ; ivylsm@163.com ; yaohuahu225@aliyun.com ; gaogcjx@163.com ; liliyao71@163.com ; gz87335487@163.net ; Huanxingsu@umac.mo ; xiongmingluo@scsio.ac.cn ; yaoshuzh@mail.sysu.edu.cn |
| 中文摘要 | Angiogenesis is the formation of blood vessels from pre-existing vasculature. Excessive or uncontrolled angiogenesis is a major contributor to many pathological conditions whereas inhibition of aberrant angiogenesis is beneficial to patients with pathological angiogenesis. Catunaregin is a core of novel marine compound isolated from mangrove associate. The potential anti-angiogenesis of catunaregin was investigated in human umbilical vein endothelial cells (HUVECs) and zebrafish. HUVECs were treated with different concentrations of catunaregin in the presence or absence of VEGF. The angiogenic phenotypes including cell invasion cell migration and tube formation were evaluated following catunaregin treatment in HUVECs. The possible involvement of AKT, eNOS and ERK1/2 in catunaregin-induced anti-angiogenesis was explored using Western blotting. The anti-angiogenesis of catunaregin was further tested in the zebrafish embryo neovascularization and caudal fin regeneration assays. We found that catunaregin dose-dependently inhibited angiogenesis in both HUVECs and zebrafish embryo neovascularization and zebrafish caudal fin regeneration assays. In addition, catunaregin significantly decreased the phosphorylation of Akt and eNOS, but not the phosphorylation of ERK1/2. The present work demonstrates that catunaregin exerts the anti-angiogenic activity at least in part through the regulation of the Akt and eNOS signaling pathways. |
| 学科主题 | Pharmacology & Pharmacy |
| 资助信息 | National Key Clinical Department; National Key Discipline; Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases; National Natural Science Foundation of China [81371255, 81100936]; Doctoral Program of Higher Education of China [20110171110058]; Young Scientists Fund of the National Natural Science Foundation of China [41006091]; Guangdong Technological grant [2010B050700024, 2011B050400031, 2012B031800107]; Natural Science Foundation of Guangdong Province [S2011010004860]; Sun Yat-sen University [2007010]; university of Macau [MYRG122 (Y1-L3)-ICMS12-SHX] |
| 收录类别 | SCI |
| 原文出处 | MDPI AG |
| WOS记录号 | WOS:000337160500024 |
| 公开日期 | 2014-12-11 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/10442]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, JX,Luo, MQ,Xia, M,et al. Marine Compound Catunaregin Inhibits Angiogenesis through the Modulation of Phosphorylation of Akt and eNOS in vivo and in vitro[J]. MARINE DRUGS,2014,12(5):2790-2801. |
| APA | Liu, JX.,Luo, MQ.,Xia, M.,Wu, Q.,Long, SM.,...&Yao, SZ.(2014).Marine Compound Catunaregin Inhibits Angiogenesis through the Modulation of Phosphorylation of Akt and eNOS in vivo and in vitro.MARINE DRUGS,12(5),2790-2801. |
| MLA | Liu, JX,et al."Marine Compound Catunaregin Inhibits Angiogenesis through the Modulation of Phosphorylation of Akt and eNOS in vivo and in vitro".MARINE DRUGS 12.5(2014):2790-2801. |
入库方式： OAI收割
来源：南海海洋研究所
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