Heterogeneous biomimetic aerobic synthesis of 3-iodoimidazo[1,2-a]pyridines via CuOx/OMS-2-catalyzed tandem cyclization/iodination and their late-stage functionalization
文献类型：期刊论文
| 作者 | Meng X(孟旭) ; Yu CY(于超英); Chen GX(陈革新); Zhao PQ(赵培庆); Zhao PQ(赵培庆); Zhao PQ(赵培庆); Zhao PQ(赵培庆)
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| 刊名 | Catalysis Scence & Technology
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| 出版日期 | 2015 |
| 卷号 | 5页码:372-379 |
| ISSN号 | 2044-4753 |
| 通讯作者 | 赵培庆 |
| 英文摘要 | In the presence of copper supported on manganese oxide-based octahedral molecular sieves OMS-2 (CuOx/OMS-2), the heterogeneously catalytic, aerobic synthesis of 3-iodoimidazo[1,2-a]pyridines from acetophenones, 2-aminopyridines and I2 via tandem cyclization/iodination in a one-pot manner is achieved. As a heterogeneous catalyst, OMS-2 acts not only as a support for catalytic Cu species but also as an electron-transfer mediator (ETM), which combines with Cu to generate a low-energy pathway for rapid electron transfer. In this way, the biomimetic, catalytic oxidation could directly employ air as a green terminal oxidant under mild conditions, and provide corresponding products with broad substrates in moderate to excellent yields using very low catalyst loading (0.2 mol% Cu). In this process, I2 not only plays the role of catalyst for the initial cyclization, with assistance from CuOx/OMS-2, but also acts as a reactant for the next electrophilic oxidative iodination, which makes the reaction highly atom economic. Besides, the late-stage functionalization of the I-substituted imidazo[1,2-a]pyridines is also demonstrated by various coupling reactions, which show its potential applications in synthetic and pharmaceutical chemistry. Moreover, the catalyst is truly heterogeneous and reusable. |
| 学科主题 | 物理化学与绿色催化 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2014-12-18 |
| 源URL | [http://210.77.64.217/handle/362003/7012]  |
| 专题 | 兰州化学物理研究所_OSSO国家重点实验室 兰州化学物理研究所_ERC国家工程研究中心 |
| 通讯作者 | Zhao PQ(赵培庆); Zhao PQ(赵培庆); Zhao PQ(赵培庆) |
| 推荐引用方式 GB/T 7714 | Meng X,Yu CY,Chen GX,et al. Heterogeneous biomimetic aerobic synthesis of 3-iodoimidazo[1,2-a]pyridines via CuOx/OMS-2-catalyzed tandem cyclization/iodination and their late-stage functionalization[J]. Catalysis Scence & Technology,2015,5:372-379. |
| APA | Meng X.,Yu CY.,Chen GX.,Zhao PQ.,赵培庆.,...&赵培庆.(2015).Heterogeneous biomimetic aerobic synthesis of 3-iodoimidazo[1,2-a]pyridines via CuOx/OMS-2-catalyzed tandem cyclization/iodination and their late-stage functionalization.Catalysis Scence & Technology,5,372-379. |
| MLA | Meng X,et al."Heterogeneous biomimetic aerobic synthesis of 3-iodoimidazo[1,2-a]pyridines via CuOx/OMS-2-catalyzed tandem cyclization/iodination and their late-stage functionalization".Catalysis Scence & Technology 5(2015):372-379. |
入库方式： OAI收割
来源：兰州化学物理研究所
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