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  2. 兰州化学物理研究所
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Adsorption and release of ofloxacin from acid- and heat-treated halloysite

文献类型：期刊论文

作者Wang Q(汪琴)1; Zhang JP(张俊平)1; Zheng Y(郑玥)2; Wang AQ(王爱勤)1; Zhang JP(张俊平)
刊名Colloids and Surfaces B: Biointerfaces
出版日期2014
卷号113期号:1页码:51-58
关键词Halloysite Acid-treatment Heat-treatment Adsorption and release Ofloxacin
ISSN号0927-7765
通讯作者张俊平
英文摘要Halloysite nanotube is an ideal vehicle of the controlled release of drugs. In this study, we systematicallyinvestigated the effects of acid- and heat-treatments on the physicochemical properties, structure andmorphology of halloysite by XRD, FTIR, SEM and TEM. Afterwards, the adsorption and in vitro release properties of halloysite for cationic ofloxacin (OFL) were evaluated. The results indicate that HCl treatment has no influence on the crystal structure of halloysite, whereas it becomes amorphous after calcined at temperature higher than 500 ℃. Both acid- and heat-treatments have no evident influence on the tubularstructure of halloysite. OFL was adsorbed onto halloysite via electrostatic interaction between protonated OFL and negative halloysite surface, cation exchange as well as electrostatic interaction between the OFL-Al3+complexes and the negative halloysite surface. Acid-treatment facilitates the release of the adsorbed OFL compared with the natural halloysite in spite of a slight decrease of adsorption capacity. However, heat-treatment results in a sharp decrease of adsorption capacity for OFL owning to the OFL-promoted dissolution of aluminum and the disappearance of the porous structure. Although heat-treatment also facilitates release of the adsorbed OFL, the amount of OFL released is in fact less than the natural halloysite owing to the very low adsorption capacity. Thus, acid-activation is an effective protocol to improve the adsorption and release of halloysite for cationic drug molecules.
学科主题环境材料与生态化学
收录类别SCI
资助信息the “National Natural Science Foundation of China” (No. 51003112);the “Special Research Fund of Scholarship of Dean of CAS”;the “Hundred Talents Program of the Chinese Academy of Sciences”
语种英语
WOS记录号WOS:000331670200007
公开日期2014-12-08
源URL[http://210.77.64.217/handle/362003/6866]  
专题兰州化学物理研究所_环境材料与生态化学研究发展中心
通讯作者Zhang JP(张俊平)
作者单位1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China
2.Nanjing Univ Chinese Med, Grad Univ, Nanjing 210046, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Wang Q,Zhang JP,Zheng Y,et al. Adsorption and release of ofloxacin from acid- and heat-treated halloysite[J]. Colloids and Surfaces B: Biointerfaces,2014,113(1):51-58.
APA Wang Q,Zhang JP,Zheng Y,Wang AQ,&张俊平.(2014).Adsorption and release of ofloxacin from acid- and heat-treated halloysite.Colloids and Surfaces B: Biointerfaces,113(1),51-58.
MLA Wang Q,et al."Adsorption and release of ofloxacin from acid- and heat-treated halloysite".Colloids and Surfaces B: Biointerfaces 113.1(2014):51-58.

入库方式： OAI收割

来源：兰州化学物理研究所

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