Facile preparation of magnetic 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes microspheres for the controlled release of ofloxacin
文献类型：期刊论文
| 作者 | Wang Q(汪琴) ; Zhang JP(张俊平); Mu B(牟斌); Fan L(范玲); Wang AQ(王爱勤); Zhang JP(张俊平)
|
| 刊名 | Carbohydrate Polymers
 |
| 出版日期 | 2014 |
| 卷号 | 102期号:2页码:877-883 |
| 关键词 | Quaternized chitosan Halloysite Spray drying Magnetic microspheres Controlled release |
| ISSN号 | 0144-8617 |
| 通讯作者 | 张俊平 |
| 英文摘要 | Magnetic microspheres, 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes/ofloxacin (HACC/Fe3O4/HNTs/OFL), for the controlled release of OFL were prepared by in situ crosslinking with glutaraldehyde in the spray-drying process. The magnetic microspheres were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis and a magnetometer. Various parameters influencing the encapsulation efficiency, drug loading and in vitro controlled release properties of the magnetic microspheres for OFL were also studied. Many stripes were formed and some tubular HNTs could be seen at higher magnification on the surface of the HACC/Fe3O4/HNTs/OFL magnetic microspheres. The magnetic microspheres show superparamagnetic property and fast magnetic response. The encapsulation efficiency and the cumulative release of OFL are closely related to HACC concentration, HNTs contents and crosslinking density. The release of OFL follows the first-order kinetics. |
| 学科主题 | 环境材料与生态化学 |
| 收录类别 | SCI |
| 资助信息 | the National Natural Science Foundation of China (No. 51003112);the “Hundred Talents Program” of the Chinese Academy of Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000331779600113 |
| 公开日期 | 2014-12-08 |
| 源URL | [http://210.77.64.217/handle/362003/6867]  |
| 专题 | 兰州化学物理研究所_环境材料与生态化学研究发展中心 |
| 通讯作者 | Zhang JP(张俊平) |
| 作者单位 | Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Q,Zhang JP,Mu B,et al. Facile preparation of magnetic 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes microspheres for the controlled release of ofloxacin[J]. Carbohydrate Polymers,2014,102(2):877-883. |
| APA | Wang Q,Zhang JP,Mu B,Fan L,Wang AQ,&张俊平.(2014).Facile preparation of magnetic 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes microspheres for the controlled release of ofloxacin.Carbohydrate Polymers,102(2),877-883. |
| MLA | Wang Q,et al."Facile preparation of magnetic 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes microspheres for the controlled release of ofloxacin".Carbohydrate Polymers 102.2(2014):877-883. |
入库方式： OAI收割
来源：兰州化学物理研究所
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