Freeze-drying: A versatile method to overcome re-aggregation and improve dispersion stability of palygorskite for sustained release of ofloxacin
文献类型：期刊论文
| 作者 | Wang Q(汪琴)1,2 ; Zhang JP(张俊平)1; Wang AQ(王爱勤)1,2; Zhang JP(张俊平)
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| 刊名 | Applied Clay Science
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| 出版日期 | 2014 |
| 卷号 | 87期号:1页码:7-13 |
| 关键词 | Palygorskite Freeze-drying Dispersion stability Adsorption capacity Release property |
| ISSN号 | 0169-1317 |
| 通讯作者 | 张俊平 |
| 英文摘要 | In order to overcome the re-aggregation of palygorskite nanofibers in the drying process, the palygorskite clay was freeze-dried instead of the traditional oven-drying after disaggregated by high-pressure homogenization. The effects of freeze-drying temperature on the microstructure and physicochemical properties of palygorskite clay were investigated by SEM, FTIR and BET. Further, the dispersion stability and rheological properties of the freeze-dried palygorskite clay as well as its adsorption and in vitro release properties for ofloxacin were studied. The results showed that the re-aggregation of palygorskite nanofibers can be successfully overcome by freeze-drying. Meanwhile, the structure and aspect ratio of palygorskite nanofibers were kept very well. Consequently, the dispersion stability and apparent viscosity of palygorskite in deionized water were enhanced compared with the traditional oven-dried sample. In addition, the freeze-drying of palygorskite induced more of the adsorbed ofloxacin to be released within 24 h although no evident increase in adsorption capacity was observed. This means that the adsorbed ofloxacin molecules remained active and most of them could be released from the freeze-dried palygorskite, which is very important for a drug delivery vehicle. Moreover, the physicochemical properties of palygorskite and the cumulative release of ofloxacin could be tuned by the freeze-drying temperature according to practical applications. |
| 学科主题 | 环境材料与生态化学 |
| 收录类别 | SCI |
| 资助信息 | the “National Natural Science Foundation of China” (no. 51003112);the “Top Hundred Talents Program of the Chinese Academy of Sciences”;the “Science and Technology Support Project of Jiangsu Provincial Sci. & Tech. Department” (no. BY2010012);the “Foundation of Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province” (no. HPK201001) |
| 语种 | 英语 |
| WOS记录号 | WOS:000330146600002 |
| 公开日期 | 2014-12-08 |
| 源URL | [http://210.77.64.217/handle/362003/6868]  |
| 专题 | 兰州化学物理研究所_环境材料与生态化学研究发展中心 |
| 通讯作者 | Zhang JP(张俊平) |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ecomat & Green Chem, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 2.Huaiyin Inst Technol, Key Lab Palygorskite Sci & Appl Technol Jiangsu P, Huaian 223003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Q,Zhang JP,Wang AQ,et al. Freeze-drying: A versatile method to overcome re-aggregation and improve dispersion stability of palygorskite for sustained release of ofloxacin[J]. Applied Clay Science,2014,87(1):7-13. |
| APA | Wang Q,Zhang JP,Wang AQ,&张俊平.(2014).Freeze-drying: A versatile method to overcome re-aggregation and improve dispersion stability of palygorskite for sustained release of ofloxacin.Applied Clay Science,87(1),7-13. |
| MLA | Wang Q,et al."Freeze-drying: A versatile method to overcome re-aggregation and improve dispersion stability of palygorskite for sustained release of ofloxacin".Applied Clay Science 87.1(2014):7-13. |
入库方式： OAI收割
来源：兰州化学物理研究所
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