Supramolecular Hybrid Hydrogel Based on Host-Guest Interaction and Its Application in Drug Delivery
文献类型：期刊论文
| 作者 | Yu J(于京)1,2,3 ; Ha W(哈伟)1,2; Sun JN(孙建楠)1,2; Shi YP(师彦平)1,2; Shi YP(师彦平)
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| 刊名 | ACS Applied Materials & Interfaces
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| 出版日期 | 2014 |
| 卷号 | 6期号:22页码:19544-19551 |
| 关键词 | supramolecular hybrid hydrogel host-guest inclusion gold nanoparticles rug delivery |
| ISSN号 | 1944-8244 |
| 通讯作者 | 师彦平 |
| 英文摘要 | In this work, we developed a simple, novel method for constructing gold nanocomposite supramolecular hybrid hydrogels for drug delivery, in which gold nanocrystals were utilized as building blocks. First, methoxypoly(ethylene glycol) thiol (mPEG-SH, molecular weight (MW) = 5 K) capped gold nanocrystals (nanospheres and nanorods) were prepared via a facile one-step ligand-exchange procedure. Then, the homogeneous supramolecular hybrid hydrogels were formed, after adding α-cyclodextrin (α-CD) into PEG-modified gold nanocrystal solutions, due to the host–guest inclusion. Both gold nanoparticles and inclusion complexes formed between α-CD and PEG chain provided the supra-cross-links, which are beneficial to the gelation formation. The resulting hybrid hydrogels were fully characterized by a combination of techniques including X-ray diffraction, rheology studies, and scanning electron microscopy. Meanwhile, the hybrid hydrogel systems demonstrated unique reversible gel–sol transition properties at a certain temperature caused by the temperature-responsive reversible supramolecular assembly. The drug delivery applications of such hybrid hydrogels were further investigated in which doxorubicin was selected as a model drug for in vitro release, cytotoxicity, and intracellular release studies. We believe that the development of such hybrid hydrogels will provide new and therapeutically useful means for medical applications. |
| 学科主题 | 分析化学与药物化学 |
| 收录类别 | SCI |
| 资助信息 | the National Nature Science Foundation of China (Nos. 21105106;21375136) |
| 语种 | 英语 |
| WOS记录号 | WOS:000345721400014 |
| 公开日期 | 2014-12-11 |
| 源URL | [http://210.77.64.217/handle/362003/6929]  |
| 专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| 通讯作者 | Shi YP(师彦平) |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Chem Northwestern Plant Resources CAS, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Nat Med Gansu Prov, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu J,Ha W,Sun JN,et al. Supramolecular Hybrid Hydrogel Based on Host-Guest Interaction and Its Application in Drug Delivery[J]. ACS Applied Materials & Interfaces,2014,6(22):19544-19551. |
| APA | Yu J,Ha W,Sun JN,Shi YP,&师彦平.(2014).Supramolecular Hybrid Hydrogel Based on Host-Guest Interaction and Its Application in Drug Delivery.ACS Applied Materials & Interfaces,6(22),19544-19551. |
| MLA | Yu J,et al."Supramolecular Hybrid Hydrogel Based on Host-Guest Interaction and Its Application in Drug Delivery".ACS Applied Materials & Interfaces 6.22(2014):19544-19551. |
入库方式： OAI收割
来源：兰州化学物理研究所
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