Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?
文献类型：SCI/SSCI论文
| 作者 | Wang Y. F. ; Pei L. J. ; Wang J. F. ; Zheng X. Y. |
| 发表日期 | 2012 |
| 关键词 | methylenetetrahydrofolic acid reductase MTHFR C677T single nucleotide polymorphism ultraviolet radiation spontaneously aborted embryos methylenetetrahydrofolate reductase 5 folate intake risk metaanalysis mutation a1298c 10-methylenetetrahydrofolate reductase |
| 英文摘要 | The methylenetetrahydrofolic acid reductase (MTHFR) C677T polymorphism causes an amino-acid change from alanine to valine and results in the enzyme becoming thermolabile and half decreased activity. Its prevalence varies among global population. We collected data about MTHFR C677T polymorphism prevalence from epidemiology studies, as well as ultraviolet (UV) radiations and some other climatological factors from the internet. The results of the correlation and quadric regression showed that there was inverse U-shape relationship between T allele frequency and UV radiation. The explanatory power of UV radiation was stronger than latitude and all climatological factors. Our results supported the hypothesis that the distribution pattern of MTFHR C677T polymorphism in Eurasia might be the result of interaction of genetic and environmental natural selection, especially the UV radiation. Journal of Human Genetics (2012) 57, 780-786; doi:10.1038/jhg.2012.113; published online 20 September 2012 |
| 出处 | Journal of Human Genetics |
| 卷 | 57 |
| 期 | 12 |
| 页 | 780-786 |
| 收录类别 | SCI |
| 语种 | 英语 |
| ISSN号 | 1434-5161 |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/30737]  |
| 专题 | 地理科学与资源研究所_历年回溯文献 |
| 推荐引用方式 GB/T 7714 | Wang Y. F.,Pei L. J.,Wang J. F.,et al. Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?. 2012. |
入库方式： OAI收割
来源：地理科学与资源研究所
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