Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles
文献类型：期刊论文
| 作者 | Zhang, Yaqin1; Liu, Bin2,3; Wu, Heming4; Li, Bin4; Xu, Junyong4; Duan, Lei2; Jiang, Caiyun5; Zhao, Xiaohui6; Yuan, Yi4; Zhang, Gen3,7 |
| 刊名 | journal of biomedical nanotechnology
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 10期号:12页码:3638-3646 |
| 关键词 | Anti-Cancer Nanoparticle VB-Au Drug-Resistant K562 Cells |
| ISSN号 | 1550-7033 |
| 中文摘要 | verbascoside (vb), a major bioactive constituent of the tsoong herb, has attracted a great deal of attention due to its pharmacological properties. in this study, we demonstrated the inhibitory effect of vb-loaded gold nanoparticles (vb-au) on the growth of k562 cells both in vitro and in vivo. we found that, in contrast with the same concentration of gold nanoparticles (au) or vb, vb-au significantly decreased the viability of k562 cells and promoted the apoptosis of tumor cells. a tumor implantation mouse model further showed that the intravenous injection of vb-au effectively inhibited the growth and induced the apoptosis of tumor cells. in conclusion, our results collectively demonstrate that vb-au nanoparticles provide an effective strategy to control tumor cell growth. |
| 英文摘要 | verbascoside (vb), a major bioactive constituent of the tsoong herb, has attracted a great deal of attention due to its pharmacological properties. in this study, we demonstrated the inhibitory effect of vb-loaded gold nanoparticles (vb-au) on the growth of k562 cells both in vitro and in vivo. we found that, in contrast with the same concentration of gold nanoparticles (au) or vb, vb-au significantly decreased the viability of k562 cells and promoted the apoptosis of tumor cells. a tumor implantation mouse model further showed that the intravenous injection of vb-au effectively inhibited the growth and induced the apoptosis of tumor cells. in conclusion, our results collectively demonstrate that vb-au nanoparticles provide an effective strategy to control tumor cell growth. |
| WOS标题词 | science & technology ; technology |
| 类目[WOS] | nanoscience & nanotechnology ; materials science, biomaterials |
| 研究领域[WOS] | science & technology - other topics ; materials science |
| 关键词[WOS] | plant-cell cultures ; fe-at-au ; biomedical applications ; magnetic nanoparticles ; electrochemical biosensor ; drug-delivery ; l-glutamate ; array ; fabrication ; leukemia |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000342793600013 |
| 公开日期 | 2014-12-19 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/4173]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Nanjing Med Univ, Sch Basic Med Sci, Dept Biochem Mol Biol, Nanjing 210029, Jiangsu, Peoples R China 2.Nanjing Med Univ, Sch Basic Med Sci, Dept Biomed Engn, Nanjing 210029, Jiangsu, Peoples R China 3.Southeast Univ, Dept Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China 4.Nanjing Med Univ, Inst Stomatol, Nanjing 210029, Jiangsu, Peoples R China 5.Jiangsu Inst Commerce, Dept Engn & Technol, Nanjing 211168, Jiangsu, Peoples R China 6.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China 7.Nanjing Med Univ, Sch Basic Med Sci, Dept Cell Biol, Nanjing 210029, Jiangsu, Peoples R China 8.Nanjing Matern & Child Hlth Care Hosp, Maternal & Child Hlth Inst, Nanjing 210029, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yaqin,Liu, Bin,Wu, Heming,et al. Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles[J]. journal of biomedical nanotechnology,2014,10(12):3638-3646. |
| APA | Zhang, Yaqin.,Liu, Bin.,Wu, Heming.,Li, Bin.,Xu, Junyong.,...&Zeng, Xin.(2014).Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles.journal of biomedical nanotechnology,10(12),3638-3646. |
| MLA | Zhang, Yaqin,et al."Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles".journal of biomedical nanotechnology 10.12(2014):3638-3646. |
入库方式： OAI收割
来源：西北高原生物研究所
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