Two New 2,3-Seco-Hopane Triterpene Derivatives from Megacodon stylophorus and Their Antiproliferative and Antimicrobial Activities
文献类型：期刊论文
| 作者 | Liu, Chao1,3; Liao, Zhi-Xin1,3; Liu, Shi-Jun1; Ji, Lan-Ju2; Sun, Hong-Fa2 |
| 刊名 | planta medica
 |
| 出版日期 | 2014-07-01 |
| 卷号 | 80期号:11页码:936-941 |
| 关键词 | Megacodon stylophorus Gentianaceae 2,3-seco-hopane triterpenoids antiproliferative antimicrobial |
| ISSN号 | 0032-0943 |
| 中文摘要 | chemical investigation of the ethanol extract of the whole plant of megacodon stylophorus led to the isolation and identification of two new secohopane triterpenoids, 2,3-seco-22(29)-hopene-2-carboxyl-3-aldehyde (1) and 2,3-seco-4(23),22 (29)-hopene-2-carboxyl-3-aldehyde (2), along with 10 known compounds, 3-12. all the isolates were reported from this plant for the first time. the structures of compounds 1 and 2 were determined by detailed analysis of their spectral data including 1d and 2d nmr. in addition, compound 1 was further analyzed by x-ray crystallography. compounds 1-3 were evaluated for their in vitro anti-proliferative activities on hela, mcf-7, and hep-g2 tumor cell lines. compound 2 was active against the three cell lines with ic50 values of 3.6, 7.5, and 13.6 mu m, respectively, while compound 1 exhibited cytotoxicity on mcf-7 (ic50 14.0 mu m) and hela (ic50 18.2 mu m) cell lines. antimicrobial activities of compounds 1-2 (minimum inhibitory concentration values in the range of 3.12-12.50 mg/ml) were also observed. |
| 英文摘要 | chemical investigation of the ethanol extract of the whole plant of megacodon stylophorus led to the isolation and identification of two new secohopane triterpenoids, 2,3-seco-22(29)-hopene-2-carboxyl-3-aldehyde (1) and 2,3-seco-4(23),22 (29)-hopene-2-carboxyl-3-aldehyde (2), along with 10 known compounds, 3-12. all the isolates were reported from this plant for the first time. the structures of compounds 1 and 2 were determined by detailed analysis of their spectral data including 1d and 2d nmr. in addition, compound 1 was further analyzed by x-ray crystallography. compounds 1-3 were evaluated for their in vitro anti-proliferative activities on hela, mcf-7, and hep-g2 tumor cell lines. compound 2 was active against the three cell lines with ic50 values of 3.6, 7.5, and 13.6 mu m, respectively, while compound 1 exhibited cytotoxicity on mcf-7 (ic50 14.0 mu m) and hela (ic50 18.2 mu m) cell lines. antimicrobial activities of compounds 1-2 (minimum inhibitory concentration values in the range of 3.12-12.50 mg/ml) were also observed. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | plant sciences ; chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | plant sciences ; pharmacology & pharmacy |
| 关键词[WOS] | cancer-cell lines ; xanthone derivatives ; centaurium-erythraea ; aerial parts ; steroids ; rats |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340577700012 |
| 公开日期 | 2014-12-19 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/4212]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Southeast Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Nanjing 211189, Jiangsu, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining, Peoples R China 3.Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Chao,Liao, Zhi-Xin,Liu, Shi-Jun,et al. Two New 2,3-Seco-Hopane Triterpene Derivatives from Megacodon stylophorus and Their Antiproliferative and Antimicrobial Activities[J]. planta medica,2014,80(11):936-941. |
| APA | Liu, Chao,Liao, Zhi-Xin,Liu, Shi-Jun,Ji, Lan-Ju,&Sun, Hong-Fa.(2014).Two New 2,3-Seco-Hopane Triterpene Derivatives from Megacodon stylophorus and Their Antiproliferative and Antimicrobial Activities.planta medica,80(11),936-941. |
| MLA | Liu, Chao,et al."Two New 2,3-Seco-Hopane Triterpene Derivatives from Megacodon stylophorus and Their Antiproliferative and Antimicrobial Activities".planta medica 80.11(2014):936-941. |
入库方式： OAI收割
来源：西北高原生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。