Development of a pair of differential H/D isotope-coded derivatization reagents d(0)/d(3)-4-(1-methyl-1H-phenanthro[9,10-d]imidazol-2-yl) phenlamine and its application for determination of aldehydes in selected aquatic products by liquid chromatography-tandem mass spectrometry.
文献类型：期刊论文
| 作者 | Sun, Zhiwei1,2; Wang, Xiaoxiang1,2; Cai, Yiping1,2; Fu, Junqing1,2; You, Jinmao1,2,3 |
| 刊名 | talanta
 |
| 出版日期 | 2014-03-01 |
| 卷号 | 120页码:84-93 |
| 关键词 | Isotope-coded Derivatization reagent HPLC-MS/MS Aliphatic aldehydes |
| ISSN号 | 0039-9140 |
| 中文摘要 | a new pair of derivatization reagents, d(0)-4-(1-methyl-1h-phenanthro[9,10-dlimidazol-2-yl)phenlamine (d(0)-mpia) and d(3)-4-(1-methyl-1h-phenanthro[9,10-d]imidazol-2-yl)phenlamine (d(3)-mpia) have been designed and synthesized. it was successfully used to label aliphatic aldehydes and the aldehyde derivatives were analyzed by high-performance liquid chromatography-tandem mass spectrometry (hplc-ms/ms). the new isotope-coded reagents could easily label aldehydes under acidic conditions in the presence of nacnbh3. the target derivatives exhibited intense [m+h](+) and regular product ions with electrospray ionization source in positive mode. the d(0)/d(3)-mpia-aldehydes were monitored by the transitions of [m+h](+) -> m/z 322 and [m+h](+) -> m/z 165, and the obtained detection limits were in the range of 0.18-15.9 pg/ml at signal to noise ratio of 3. the global isotope internal standard technology was employed for quantification analysis with d(3)-mpia-aldehyde as internal standard for corresponding d(0)-mpia-aldehyde. excellent linear responses for relative quantification were observed in the range of 1/10-10/1 with coefficients > 0.998. the developed method has been applied to the quantification of aliphatic aldehydes in selected aquatic products with rsd <3.6% and recoveries > 85.2%. (c) 2013 elsevier b.v. all rights reserved. |
| 英文摘要 | a new pair of derivatization reagents, d(0)-4-(1-methyl-1h-phenanthro[9,10-dlimidazol-2-yl)phenlamine (d(0)-mpia) and d(3)-4-(1-methyl-1h-phenanthro[9,10-d]imidazol-2-yl)phenlamine (d(3)-mpia) have been designed and synthesized. it was successfully used to label aliphatic aldehydes and the aldehyde derivatives were analyzed by high-performance liquid chromatography-tandem mass spectrometry (hplc-ms/ms). the new isotope-coded reagents could easily label aldehydes under acidic conditions in the presence of nacnbh3. the target derivatives exhibited intense [m+h](+) and regular product ions with electrospray ionization source in positive mode. the d(0)/d(3)-mpia-aldehydes were monitored by the transitions of [m+h](+) -> m/z 322 and [m+h](+) -> m/z 165, and the obtained detection limits were in the range of 0.18-15.9 pg/ml at signal to noise ratio of 3. the global isotope internal standard technology was employed for quantification analysis with d(3)-mpia-aldehyde as internal standard for corresponding d(0)-mpia-aldehyde. excellent linear responses for relative quantification were observed in the range of 1/10-10/1 with coefficients > 0.998. the developed method has been applied to the quantification of aliphatic aldehydes in selected aquatic products with rsd <3.6% and recoveries > 85.2%. (c) 2013 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | aliphatic-aldehydes ; carbonyl-compounds ; labeling reagent ; oxidative damage ; microextraction ; 2,4-dinitrophenylhydrazine ; quantitation ; derivatives ; metabolite ; hydrazine |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331917700013 |
| 公开日期 | 2014-12-19 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/4250]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Qufu Normal Univ, Key Lab LifeOrgan Anal Shandong Prov, Qufu, Peoples R China 2.Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Zhiwei,Wang, Xiaoxiang,Cai, Yiping,et al. Development of a pair of differential H/D isotope-coded derivatization reagents d(0)/d(3)-4-(1-methyl-1H-phenanthro[9,10-d]imidazol-2-yl) phenlamine and its application for determination of aldehydes in selected aquatic products by liquid chromatography-tandem mass spectrometry.[J]. talanta,2014,120:84-93. |
| APA | Sun, Zhiwei,Wang, Xiaoxiang,Cai, Yiping,Fu, Junqing,&You, Jinmao.(2014).Development of a pair of differential H/D isotope-coded derivatization reagents d(0)/d(3)-4-(1-methyl-1H-phenanthro[9,10-d]imidazol-2-yl) phenlamine and its application for determination of aldehydes in selected aquatic products by liquid chromatography-tandem mass spectrometry..talanta,120,84-93. |
| MLA | Sun, Zhiwei,et al."Development of a pair of differential H/D isotope-coded derivatization reagents d(0)/d(3)-4-(1-methyl-1H-phenanthro[9,10-d]imidazol-2-yl) phenlamine and its application for determination of aldehydes in selected aquatic products by liquid chromatography-tandem mass spectrometry.".talanta 120(2014):84-93. |
入库方式： OAI收割
来源：西北高原生物研究所
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