A Review on Differential Isotope-coded Derivatization Reagents for LC-API-MS Analyses
文献类型：期刊论文
| 作者 | Sun, Zhiwei1; Sun, Haiyi1; Li, Hongtao1; You, Jinmao1,2; Xia, Lian1 |
| 刊名 | current analytical chemistry
 |
| 出版日期 | 2014 |
| 卷号 | 10期号:3页码:381-392 |
| 关键词 | Atmospheric pressure ionization high performance liquid chromatography isotope-coded derivatization reagent mass spectrometry |
| ISSN号 | 1573-4110 |
| 中文摘要 | high-performance liquid chromatography coupling with atmospheric pressure ionization mass spectrometry (lc-api-ms) has been widely used in the pharmaceutical industry, clinical research, environmental science, metabolomics studies and so on. however, lc-api-ms often suffers from the matrix effect in its applications in complex samples. matrix effects can heavily affect reproducibility, linearity, and accuracy of the method leading to erroneous quantitation. the use of isotope-labeled analyte as internal standards provides an efficient solution to overcome matrix effects in lc-api-ms analysis. however, the isotope-labeled standards are expensive and not always available, especially in the analysis of large numbers of analytes. in recent years, the stable isotope-coded derivatization reagents, as an alternative way, have been used to quantify small molecules in lc-api-ms analysis of complex samples. in this review, an overview of differential isotope-coded derivatization reagents is presented, focusing on the applications to low molecular weight compounds by lc-api-ms. the recently reported isotope-coded derivatization reagents were summarized in category of their target analytes, specifically peptides, amines, phenols, carboxylic acids, aldehyde or ketone, saccharides and thiols. it indicates that isotope-labeled derivatization reagent would have an increasingly wide range of applications in the lc-api-ms analysis. |
| 英文摘要 | high-performance liquid chromatography coupling with atmospheric pressure ionization mass spectrometry (lc-api-ms) has been widely used in the pharmaceutical industry, clinical research, environmental science, metabolomics studies and so on. however, lc-api-ms often suffers from the matrix effect in its applications in complex samples. matrix effects can heavily affect reproducibility, linearity, and accuracy of the method leading to erroneous quantitation. the use of isotope-labeled analyte as internal standards provides an efficient solution to overcome matrix effects in lc-api-ms analysis. however, the isotope-labeled standards are expensive and not always available, especially in the analysis of large numbers of analytes. in recent years, the stable isotope-coded derivatization reagents, as an alternative way, have been used to quantify small molecules in lc-api-ms analysis of complex samples. in this review, an overview of differential isotope-coded derivatization reagents is presented, focusing on the applications to low molecular weight compounds by lc-api-ms. the recently reported isotope-coded derivatization reagents were summarized in category of their target analytes, specifically peptides, amines, phenols, carboxylic acids, aldehyde or ketone, saccharides and thiols. it indicates that isotope-labeled derivatization reagent would have an increasingly wide range of applications in the lc-api-ms analysis. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | chromatography-mass-spectrometry ; liquid-chromatography ; quantitative proteomics ; relative quantification ; electrospray-ionization ; esi-ms ; sulfonamide antibacterials ; containing metabolites ; internal standard ; labeling reagent |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337253600011 |
| 公开日期 | 2014-12-19 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/4276]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Qufu Normal Univ, Key Lab Life Organ Anal Shandong Prov, Qufu 273165, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810008, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Zhiwei,Sun, Haiyi,Li, Hongtao,et al. A Review on Differential Isotope-coded Derivatization Reagents for LC-API-MS Analyses[J]. current analytical chemistry,2014,10(3):381-392. |
| APA | Sun, Zhiwei,Sun, Haiyi,Li, Hongtao,You, Jinmao,&Xia, Lian.(2014).A Review on Differential Isotope-coded Derivatization Reagents for LC-API-MS Analyses.current analytical chemistry,10(3),381-392. |
| MLA | Sun, Zhiwei,et al."A Review on Differential Isotope-coded Derivatization Reagents for LC-API-MS Analyses".current analytical chemistry 10.3(2014):381-392. |
入库方式： OAI收割
来源：西北高原生物研究所
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