Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides
文献类型：期刊论文
| 作者 | Wu, Hai-Yan1,2; Wang, Wei-Guang1; Jiang, Hua-Yi1,2; Du, Xue1; Li, Xiao-Nian1; Pu, Jian-Xin1 ; Sun, Han-Dong1
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2014-10-01 |
| 卷号 | 98页码:192-198 |
| ISSN号 | 0367-326X |
| 关键词 | Lamiaceae Isodon wikstroemioides ent-Kaurane diterpenoid Cytotoxicity |
| 通讯作者 | Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 产权排序 | 第一 |
| 英文摘要 | Seven new ent-kaurane diterpenoids, isowikstroemins A-G (1-7), were isolated from EtOAc extracts of the aerial parts of Isodon wikstroemioides. Their structures were elucidated by extensive spectroscopic analysis. The isolates were evaluated for their cytotoxicity against five human tumor cell lines, and compounds 1-4 exhibited significant activity with IC50 values ranging from 0.9 to 7.0 mu M. In addition, compounds 1, 2, 3, 4, and 7 exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages. (C) 2014 Elsevier B.V. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | WIKSTROEMIOIDES |
| 资助信息 | National Natural Science Foundation of China [21322204, 81172939]; NSFC-Joint Foundation of Yunnan Province [U1302223]; Yunnan Province [2011C1043]; Major Direction Projection Foundation of CAS Intellectual Innovation Projec [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343617600028 |
| 公开日期 | 2014-11-25 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/18382]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Hai-Yan,Wang, Wei-Guang,Jiang, Hua-Yi,et al. Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides[J]. FITOTERAPIA,2014,98:192-198. |
| APA | Wu, Hai-Yan.,Wang, Wei-Guang.,Jiang, Hua-Yi.,Du, Xue.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2014).Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides.FITOTERAPIA,98,192-198. |
| MLA | Wu, Hai-Yan,et al."Cytotoxic and anti-inflammatory ent-kaurane diterpenoids from Isodon wikstroernioides".FITOTERAPIA 98(2014):192-198. |
入库方式： OAI收割
来源：昆明植物研究所
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