Prediction of protein-RNA residue-base contacts using two-dimensional conditional random field with the lasso
文献类型：期刊论文
| 作者 | Hayashida, Morihiro1; Kamada, Mayumi1; Song, Jiangning2,3; Akutsu, Tatsuya1 |
| 刊名 | BMC SYSTEMS BIOLOGY
 |
| 出版日期 | 2013-12-17 |
| 卷号 | 7期号:7 |
| 英文摘要 | Background: To uncover molecular functions and networks in biological cellular systems, it is important to dissect interactions between proteins and RNAs. Many studies have been performed to investigate and analyze interactions between protein amino acid residues and RNA bases. In terms of interactions between residues in proteins, it is generally accepted that an amino acid residue at interacting sites has coevolved together with the partner residue in order to keep the interaction between residues in proteins. Based on this hypothesis, in our previous study to identify residue-residue contact pairs in interacting proteins, we made calculations of mutual information (M I) between amino acid residues from some multiple sequence alignment of homologous proteins, and combined it with a discriminative random field (DRF) approach, which is a special type of conditional random fields (CRFs) and has been proved useful for the purpose of extracting distinguishing areas from a photograph in the image processing field. Recently, the evolutionary correlation of interactions between residues and DNA bases has also been found in certain transcription factors and the DNA-binding sites. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Mathematical & Computational Biology |
| 研究领域[WOS] | Mathematical & Computational Biology |
| 关键词[WOS] | BINDING-SITES ; ENERGY MINIMIZATION ; INFORMATION ; IDENTIFICATION ; RECOGNITION ; FEATURES |
| 收录类别 | SCI ; ISTP |
| 语种 | 英语 |
| WOS记录号 | WOS:000329440000007 |
| 公开日期 | 2014-11-23 |
| 源URL | [http://124.16.173.210/handle/311007/428]  |
| 专题 | 天津工业生物技术研究所_结构生物信息学和整合系统生物学实验室 宋江宁_期刊论文 |
| 作者单位 | 1.Kyoto Univ, Inst Chem Res, Bioinformat Ctr, Kyoto 6110011, Japan 2.Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hayashida, Morihiro,Kamada, Mayumi,Song, Jiangning,et al. Prediction of protein-RNA residue-base contacts using two-dimensional conditional random field with the lasso[J]. BMC SYSTEMS BIOLOGY,2013,7(7). |
| APA | Hayashida, Morihiro,Kamada, Mayumi,Song, Jiangning,&Akutsu, Tatsuya.(2013).Prediction of protein-RNA residue-base contacts using two-dimensional conditional random field with the lasso.BMC SYSTEMS BIOLOGY,7(7). |
| MLA | Hayashida, Morihiro,et al."Prediction of protein-RNA residue-base contacts using two-dimensional conditional random field with the lasso".BMC SYSTEMS BIOLOGY 7.7(2013). |
入库方式： OAI收割
来源：天津工业生物技术研究所
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