Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets
文献类型：期刊论文
| 作者 | Wang, Mingjun1,2; Zhao, Xing-Ming3; Tan, Hao4; Akutsu, Tatsuya5; Whisstock, James C.4,6; Song, Jiangning1,2,4,6 |
| 刊名 | BIOINFORMATICS
 |
| 出版日期 | 2014 |
| 卷号 | 30期号:1页码:71-80 |
| 英文摘要 | Motivation: Caspases and granzyme B (GrB) are important proteases involved in fundamental cellular processes and play essential roles in programmed cell death, necrosis and inflammation. Although a number of substrates for both types have been experimentally identified, the complete repertoire of caspases and granzyme B substrates remained to be fully characterized. Accordingly, systematic bioinformatics studies of known cleavage sites may provide important insights into their substrate specificity and facilitate the discovery of novel substrates. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences |
| 类目[WOS] | Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology ; Statistics & Probability |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics |
| 关键词[WOS] | PROTEOLYTIC CLEAVAGE ; SECONDARY STRUCTURE ; PEPTIDE LIBRARIES ; PROTEIN SEQUENCES ; CELL-DEATH ; WEB SERVER ; REG-GAMMA ; DATABASE ; SITES ; SUBSTRATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000329059700010 |
| 公开日期 | 2014-11-23 |
| 源URL | [http://124.16.173.210/handle/311007/431]  |
| 专题 | 天津工业生物技术研究所_结构生物信息学和整合系统生物学实验室 宋江宁_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China 3.Tongji Univ, Sch Elect & Informat Engn, Dept Comp Sci, Shanghai 201804, Peoples R China 4.Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic 3800, Australia 5.Kyoto Univ, Inst Chem Res, Bioinformat Ctr, Uji, Kyoto 6110011, Japan 6.Monash Univ, ARC Ctr Excellence Struct & Funct Microbial Genom, Melbourne, Vic 3800, Australia |
| 推荐引用方式 GB/T 7714 | Wang, Mingjun,Zhao, Xing-Ming,Tan, Hao,et al. Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets[J]. BIOINFORMATICS,2014,30(1):71-80. |
| APA | Wang, Mingjun,Zhao, Xing-Ming,Tan, Hao,Akutsu, Tatsuya,Whisstock, James C.,&Song, Jiangning.(2014).Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets.BIOINFORMATICS,30(1),71-80. |
| MLA | Wang, Mingjun,et al."Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets".BIOINFORMATICS 30.1(2014):71-80. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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