Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis
文献类型：期刊论文
| 作者 | Chan, Hsiu-Chien1; Feng, Xinxin2; Ko, Tzu-Ping3; Huang, Chun-Hsiang1; Hu, Yumei1; Zheng, Yingying1; Bogue, Shannon2; Nakano, Chiaki4; Hoshino, Tsutomu4; Zhang, Lilan1 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2014-02-19 |
| 卷号 | 136期号:7页码:2892-2896 |
| 英文摘要 | We have obtained the structure of the bacterial diterpene synthase, tuberculosinol/iso-tuberculosinol synthase (Rv3378c) from Mycobacterium tuberculosis, a target for anti-infective therapies that block virulence factor formation. This phosphatase adopts the same fold as found in the Z- or cis-prenyltransferases. We also obtained structures containing the tuberculosinyl diphosphate substrate together with one bisphosphonate inhibitor-bound structure. These structures together with the results of site-directed mutagenesis suggest an unusual mechanism of action involving two Tyr residues. Given the similarity in local and global structure between Rv3378c and the M. tuberculosis cis-decaprenyl diphosphate synthase (DPPS; Rv2361c), the possibility exists for the development of inhibitors that target not only virulence but also cell wall biosynthesis, based in part on the structures reported here. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | DITERPENE CYCLASE ; EDAXADIENE ; VIRULENCE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331779800030 |
| 公开日期 | 2014-12-23 |
| 源URL | [http://124.16.173.210/handle/311007/545]  |
| 专题 | 天津工业生物技术研究所_结构生物学与蛋白酶学实验室 郭瑞庭_期刊论文 |
| 作者单位 | 1.Tianjin Inst Ind Biotechnol, Ind Enzymes Natl Engn Lab, Tianjin 300308, Peoples R China 2.Univ Illinois, Dept Chem, Urbana, IL 61801 USA 3.Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan 4.Niigata Univ, Dept Appl Biol Chem, Niigata 9502181, Japan 5.Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA |
| 推荐引用方式 GB/T 7714 | Chan, Hsiu-Chien,Feng, Xinxin,Ko, Tzu-Ping,et al. Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(7):2892-2896. |
| APA | Chan, Hsiu-Chien.,Feng, Xinxin.,Ko, Tzu-Ping.,Huang, Chun-Hsiang.,Hu, Yumei.,...&Guo, Rey-Ting.(2014).Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(7),2892-2896. |
| MLA | Chan, Hsiu-Chien,et al."Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.7(2014):2892-2896. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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