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Visualizing an emotional valence map in the limbic forebrain by TAI-FISH
文献类型：期刊论文
| 作者 | Xiu, JB ; Zhang, Q ; Zhou, T ; Zhou, TT ; Chen, Y ; Hu, HL |
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2014 |
| 卷号 | 17期号:11页码:1552-1559 |
| ISSN号 | 1097-6256 |
| 关键词 | MEDIUM SPINY NEURONS NUCLEUS-ACCUMBENS C-FOS STRIATAL NEURONS CONDITIONED FEAR DISTINCT ROLES BASAL GANGLIA BRAIN EXPRESSION DOPAMINE |
| 通讯作者 | Hu, HL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China.,hailan@ion.ac.cn |
| 英文摘要 | A fundamental problem in neuroscience is how emotional valences are represented in the brain. We know little about how appetitive and aversive systems interact and the extent to which information regarding these two opposite values segregate and converge. Here we used a new method, tyramide-amplified immunohistochemistry-fluorescence in situ hybridization, to simultaneously visualize the neural correlates of two stimuli of contrasting emotional valence across the limbic forebrain at single-cell resolution. We discovered characteristic patterns of interaction, segregated, convergent and intermingled, between the appetitive and aversive neural ensembles in mice. In nucleus accumbens, we identified a mosaic activation pattern by positive and negative emotional cues, and unraveled previously unappreciated functional heterogeneity in the D1- and D2-type medium-spiny neurons, which correspond to the Go and No Go pathways. These results provide insights into the coding of emotional valence in the brain and act as a proof of principle of a powerful methodology for simultaneous functional mapping of two distinct behaviors. |
| 学科主题 | Neurosciences |
| 资助信息 | Chinese 973 Program [2011CBA00400]; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB02030004]; One Hundred Talents Program; Outstanding Youth Grant |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2014-12-15 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2636]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Xiu, JB,Zhang, Q,Zhou, T,et al. Visualizing an emotional valence map in the limbic forebrain by TAI-FISH[J]. NATURE NEUROSCIENCE,2014,17(11):1552-1559. |
| APA | Xiu, JB,Zhang, Q,Zhou, T,Zhou, TT,Chen, Y,&Hu, HL.(2014).Visualizing an emotional valence map in the limbic forebrain by TAI-FISH.NATURE NEUROSCIENCE,17(11),1552-1559. |
| MLA | Xiu, JB,et al."Visualizing an emotional valence map in the limbic forebrain by TAI-FISH".NATURE NEUROSCIENCE 17.11(2014):1552-1559. |
入库方式： OAI收割
来源：上海神经科学研究所
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