Medial prefrontal activity during delay period contributes to learning of a working memory task
文献类型：期刊论文
| 作者 | Liu, D ; Gu, XW ; Zhu, J ; Zhang, XX ; Han, Z ; Yan, WJ ; Cheng, Q ; Hao, J ; Fan, HM ; Hou, RQ ; Chen, ZQ ; Chen, YL ; Li, CYT |
| 刊名 | SCIENCE
 |
| 出版日期 | 2014 |
| 卷号 | 346期号:6208页码:458-463 |
| 关键词 | SHORT-TERM-MEMORY NEURAL MECHANISMS CORTICAL ACTIVITY CORTEX DYNAMICS DECISION RAT INFORMATION ACQUISITION LESIONS |
| ISSN号 | 0036-8075 |
| 通讯作者 | Li, CYT (reprint author), Friedrich Miescher Inst Biomed Res, Maulbeerstr 66, CH-4058 Basel, Switzerland.,tonylicy@ion.ac.cn |
| 英文摘要 | Cognitive processes require working memory (WM) that involves a brief period of memory retention known as the delay period. Elevated delay-period activity in the medial prefrontal cortex (mPFC) has been observed, but its functional role in WM tasks remains unclear. We optogenetically suppressed or enhanced activity of pyramidal neurons in mouse mPFC during the delay period. Behavioral performance was impaired during the learning phase but not after the mice were well trained. Delay-period mPFC activity appeared to be more important in memory retention than in inhibitory control, decision-making, or motor selection. Furthermore, endogenous delay-period mPFC activity showed more prominent modulation that correlated with memory retention and behavioral performance. Thus, properly regulated mPFC delay-period activity is critical for information retention during learning of a WM task. |
| 学科主题 | Multidisciplinary Sciences |
| 收录类别 | SCI |
| 资助信息 | Chinese 973 Program [2011CBA00406]; State Key Laboratory of Neuroscience; Chinese Academy of Sciences Hundreds of Talents Program |
| 语种 | 英语 |
| 公开日期 | 2014-12-15 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/2638]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Liu, D,Gu, XW,Zhu, J,et al. Medial prefrontal activity during delay period contributes to learning of a working memory task[J]. SCIENCE,2014,346(6208):458-463. |
| APA | Liu, D.,Gu, XW.,Zhu, J.,Zhang, XX.,Han, Z.,...&Li, CYT.(2014).Medial prefrontal activity during delay period contributes to learning of a working memory task.SCIENCE,346(6208),458-463. |
| MLA | Liu, D,et al."Medial prefrontal activity during delay period contributes to learning of a working memory task".SCIENCE 346.6208(2014):458-463. |
入库方式： OAI收割
来源：上海神经科学研究所
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